In the year of 2054 a young soldier named Jack Mitchell enters the United States Army with his friend Will Irons, commanded by Sergeant Cormack, the main objective is to secure the capital of South Korea, Seoul which is guarded by the North Korean army, after passing through the semi-destroyed city, an airplane arrives to support the North Koreans (Havoc Shuttle), then Will and Mitchell try to destroy it with loads, but Will's arm gets stuck in the plane's door, and explodes, killing William and with the debris of the plane, cutting off Mitchell's arm, then Mitchell is operated and released for his injuries.
At Will's funeral, Mitchell meets his friend's father, Jonathan Irons, who owns an American defense corporation called Atlas, so Mitchell fearing a possible global catastrophe joins Atlas, there he meets Gideon and Ilona, two Atlas soldiers , It should also be noted that they build a robotic arm, due to the amputation of his arm in "Initiation", they train him in the shooting range, and they give him weapons for the next missions that will be done in the game going on, through the Lagos, Seattle, Detroit, etc. In the mission "Human Hunting". Atlas tries to stop the KVA, trying to kill Hades, trying to infiltrate the building where the main leaders of the KVA are located, so Mitchell tries to kill Hades with a drone, but it turned out that it was a trap and the one that Mitchell killed it was Hades, if not a double, who had put a bomb in the room, killing several soldiers, then we must go to the streets, following the trail to Hades, after facing waves of enemies, a speeding truck crashes and runs over Mitchell, then Hades arrives in order to kill the two, but Mitchell manages to cut Hades' throat to kill him, ending the mission.
Atlas achieves his most important victory, killing Hades, so Jonathan Irons becomes a global hero. Then Mitchell and Ilona find an old file, which contains a message from a scientist who collaborated to make Manticore, a lethal virus that is capable of killing hundreds of soldiers in a minute, then Irons is seen shooting him in the head with a Atlas 45, Mitchell and Ilona feel betrayed, then armored agents arrive from Atlas, who threaten to shoot them, but then Mitchell manages to kill them and flee from New Baghdad and are rescued by Mitchell's former sergeant, Cormack, then join Sentinel, and there they realize that Irons is the real enemy, then they head to Antarctica to seize an Atlas base, but they discover them and when they were about to capture them, Gideon kills the soldiers who were targeting them, too apologizing to them for not joining Sentinel before, after facing Atlas soldiers they arrive at the secret base at which Gideon gives Mitchell an Stinger M7 to shoot down a plane n with cargo destined for Irons.
Then they discover that this cargo has the "Manticore" virus, Atlas has the antidote for the enemy troops to die and the Atlas troops survive such a lethal encounter, then they go to an old refinery in Strandja, Bulgaria in order to destroy the Manticore plants, after this mission they go to San Francisco to take down the enemy UAVs and prevent the city from being destroyed by Atlas, after passing the Golden Gate, they arrive at the Golden Gate Strait to seize the area. After this, go to New Baghdad to carry out an attack on the Atlas base, but there Mitchell, Ilona, Gideon and Cormack were captured by Atlas because Manticore weakened them and they face each other with Irons, which destroyed him Mitchell's arm and shot at Cormack, which left him very weak, Irons escapes, like Mitchell and the others, in this mission he will go through the main base of Atlas, here you will see many bodies on stretchers or hung , consequence of Manticore. After this mission they head to New Baghdad in search of Irons. When Cormack arrives, he dies of bleeding due to the shot of Jonathan Irons, they also learn that Irons plans to bomb US with Manticore missiles, killing many innocent people. There was no hope that the three of them could against an army of more than 100,000 men, so they devised the plan to enter the base with turret suits, rockets and missiles equipped, called Goliath, after crossing the base, fighting with armored soldiers and Goliaths, arrive at a building where Irons hacks his exos, unable to move, Mitchell breaks free of his exo and chases Irons who pulls the building, killing him, in the end Mitchell's voice is heard for one last time in the game, implying that Irons may have had good reason to do what he did, but that didn't stop him from killing him.