Akrapovic

Silvio Elías, founder of the Veritas bio chains, is a pioneer in Spain in global ecology. Close to the Circuit de Catalunya, Formula 1 pilots are getting excited to go to the hotel He says that when he had children, he became more aware of the need to consume organic products. Son of the founder of Caprabo, Silvio Elías is a committed guy who created the phenomenon of Veritas supermarkets, where everything is ecological, a chain in full expansion throughout Spain. And from that attachment to the natural came the idea of creating Mas Salagros, the first 100% ecological hotel in the country. The eco-resort Mas Salagros, in Vallromanes. The eco-resort Mas Salagros, in Vallromanes. Elías was the first to think that an ecological resort could work. Located 20 minutes from Barcelona, in Vallromanes, in a farmhouse of 1497, the hotel is unique. It has a spa managed by the international firm AIRE Ancient Baths, a center to which the women of the Catalan upper bourgeoisie are assiduous. Inspired by Greek and Roman luxury spas, AIRE is a beauty and wellness center where there is a circuit of water and aromatherapy. In Mas Salagros they intend for the center of Vallromanes to become a reference, as is that of Barcelona. The AIRE spa, inspired by Greco-Roman luxury. The AIRE spa, inspired by Greco-Roman luxury. Formula 1 shelter There is also special dedication to organic gastronomy, where 100% natural materials are fused with very advanced culinary techniques, which has turned the place into a gastronomic destination. The obsession with everything ecological has led to the eco-resort two Tesla pumps. Thus, they have adhered to the Destination Charging program of the car company, whereby they provide guests with the possibility of charging their electric vehicle. Silvio Elías in the gardens of Mas Salagros. (Photo: DR) Silvio Elías in the gardens of Mas Salagros. (Photo: DR) It is not the only thing related to the engine. Due to the proximity to the Montmeló Circuit and its facilities, the resort becomes a favorite for the teams and for motor enthusiasts. The slopes of Montmeló are 10 minutes away by car and every year, the Formula 1 Grand Prix of Spain is held at its facilities bringing together more than 130,000 people. And everyone gets excited to go.

The former player is accused of drug trafficking and concert-related crimes to commit crimes. President Iván Duque signed on Thursday night the extradition of former soccer player Jhon Viáfara, who is accused of drug trafficking in the United States. Related topics Supreme Court of Jus ... Oct 09 Court frees Maduro's opponent who secured asylum in Colombia JEP Oct 08 JEP opens door to extradition for drug trafficking of Farc deserter Nicolas Mature Oct 03 Maduro's opponent who is still imprisoned in Colombia despite achieving asylum Duque's signature comes after just a few weeks ago the Supreme Court of Justice will endorse the request for extradition issued by US authorities that require the former soccer player for drug trafficking and "concert-related crimes to commit crimes." The Court reiterated to the National Government that its duty is to ensure that Viáfara is not subject to the death penalty, or that he is tried for crimes that are not included in the extradition request of the Court of the Eastern District of Texas. There is a penalty that has no proportion: Duke on Andrés F. Arias Uribismo proposes knocking down decisions of the Court Petro responds to Ángela Robledo: 'Human Colombia is respected' The former footballer had called last June for the simplified extradition - express - which the high court says is appropriate. The process began in March of this year, when Jhon Viáfara was captured in the vicinity of Jamundí in Valle del Cauca. During his transfer to Bogotá he said: "I am innocent." (Also read: Critique of Viáfara, where appropriate, for possible links with drug trafficking) Viáfara, 40, was captured in Robles, a corregimiento of Jamundí, where the Anti-Narcotics Police arrived to enforce an arrest warrant for extradition purposes issued by a Texas court. According to the information provided at the time by the Police, the monitoring of Viáfara and the network of which, according to the US authorities, was part, began after the seizure in international waters of 2,500 kilos of cocaine. Jhon Viáfara was part of the Once Caldas team that in 2004 was crowned Copa Libertadores champion.

Honda has just registered a patent for a HUD (Head-up Display) display system, that is, of information projected on a surface. In the drawing of this patent the information is projected on a concrete surface, in this case, the Africa Twin front fairing, but in another drawing of the patent it is also projected on the tank of a CBR. Honda has just registered a patent for a HUD (Head-up Display) display system, that is, of information projected on a surface. In the drawing of this patent the information is projected on a specific surface, in this case, the Africa Twin front fairing, but in another drawing of the patent it is also projected on the tank of a CBR. This system has been used for years in the automobile industry and in some cases it is tactile, that is, it can interact in the same projected image. As is the case with cars, HUD systems come from the need to show more information on current vehicles, increasingly sophisticated electronically, in addition to the ever more succesful connectivity with smartphones, ARAS systems, etc. In the case of a motorcycle, in addition, the smaller size of the dashboard means that all the necessary information cannot be displayed unless it is based on navigating in several menus, with the inconvenience and dangerous loss of attention that this entails.

The defeat against Tolima complicated the picture for the team led by Jorge Luis Pinto. Millionaires have three gears, dry braking, and being fighting the tip of the championship now puts their classification at risk, after the 2-0 defeat against Tolima, in Ibagué. And the calendar ahead is not easy. Related topics Millonaries FC 08:30 p.m. The bad hour of Millos: new and painful stumble in the League Jorge Luis Pinto 07:34 p.m. The question that indisposed Jorge Luis Pinto Millonaries FC 07:34 p.m. The concerns that Pinto had left after the defeat of Millos On Saturday, the team led by Jorge Luis Pinto receives America in Bogotá. Then, on date 18, he will visit Junior in Barranquilla. Then he will face Santa Fe in the classic and close as a visitor against Rionegro. The bad hour of Millos: new and painful stumble in the League Tremendous surprise took the Oil Alliance Why are Millionaires falling and now in trouble to classify? Here, five reasons. 1. You have no security in the defense. The coach Pinto had rehearsed several pairs of centrals and none had given him a satisfactory performance, to such an extent that in 16 games, Millionaires have only taken the goal twice at zero. In Ibagué tried to play something else: put three defenders and advanced to the sides. But with that formula, they scored a head goal, in a tremendous passivity of the defense. Luis Payares Luis Payares Photo: Instagram @ payares_30 2. No mark in half. In Ibagué, Pinto decided to rest Jhon Fredy Duque and put together a recovery couple with Felipe Jaramillo and César Carrillo. But the former has been at a very low level for a while and the latter is more of a mixed flyer than a brand man. The team gave many freedoms and did not lose any further due to the lack of aim of Tolima and the performance of Jefersson Martínez, who failed in the first goal but avoided at least two others. 3. Without creation. In the last two games, Millionaires made just two shots to the goal. And both were in the encounter against Patriots. Mackálister Silva, with everything and his intermittences, is the only one who brings offensive ideas. In Ibagué he did not play because of physical problems. And his replacement, Juan Camilo Salazar, is far from the level that led him to go to San Lorenzo. Since he returned, he hasn't even had an acceptable level. Juan Camilo Salazar Juan Camilo Salazar has not responded. Photo: Guillermo Ossa / CEET 4. Short payroll and no variants. In practice, Millos had five casualties in Ibagué: goalkeeper Wuilker Faríñez and striker José Guillermo Ortiz were with their respective teams. Silva and Cristian Arango were not available due to inconvenience and Pinto left Duque out. The team does not have a bank: there are players who have contributed little to the team, such as Salazar and Elíser Quiñones, and others who do not know what they play, because they do not enter, like Carlos López. 5. Lack of self-criticism. Jorge Luis Pinto, the Millionaire coach, appeals to memory and remembers his career every time he receives a criticism of the operation of his team. But the reality is that he has not found the return to the defense (in the last five games he has not repeated the back line) and the team is playing worse and worse. In addition, incredibly, he left the team without strikers after the expulsion of Rambal: he tried to have the ball with the entry of Barreto. How to regain campus confidence? He has a hard job ahead.

The designer has not come accompanied by her boyfriend, Luis Miguel Rodríguez (the scrap metal) to the wedding of the Duke of Huéscar and Sofía Palazuelo. What would Ágatha Ruiz de la Prada go to a wedding? You don't have to be Rappel or Esperanza Gracia to guess it: from herself. So the surprises that the ex-wife of Pedro J. Ramírez could hold at the wedding of the Duke of Huéscar and Sofía Palazuelo were few. Rather know who would accompany her to one of the most anticipated links of the year and how far she had taken the 'pantone' and the geometries in the design she wore. Regarding the first question, his companions, there has been surprise. It would have been a good time to officiate (in an area as select as this) his courtship with Luis Miguel Rodríguez (po[CENSORED]rly known as 'the scrap metal', formerly of Carmen Martínez Bordiú), but we have been left wanting .. Although the relationship, it seems, is going through a great moment. [READ MORE: Ágatha Ruiz de la Prada and Luis Miguel Rodríguez formalize their relationship with an inn] Upon arrival at the Palacio de Liria. (Cordon Press) Upon arrival at the Palacio de Liria. (Cordon Press) Ágatha has decided to go with her two children, Cósima and Tristán. The first has chosen a 'made in mama' style, which speaks for itself in the images, but we cannot ignore that it is an implicit (and explicit) homage to bullfighting, with cape and montera included and to which it does not I would have made disgust, far from it, the Infanta Elena, whom we have seen dressed as a bullfighter from Lorenzo Caprile some years ago. [READ MORE: Infanta Elena, dressed to kill in Stockholm] The designer, on the other hand, has also opted for a butt colorful dress, which is how she sees the world, with frills and leaving her arms in the air, since it is already known to everyone that after her divorce from Pedro J. Ramírez Ágatha put on the batteries and sports a splendid silhouette, besides being very rejuvenated. The touch of discretion was put by Tristan, with a simple gray suit and a simple tie that gave him a little touch of color.

That told the young woman when asked about the moment when the former congresswoman takes off her pants in the dental office, shortly before escaping. The confession was given by Aída Victoria Merlano, in an interview with Caracol News, where she said that what her mother did that day (October 1), and that she was recorded in a video, was to take off “a jean that is on top” to stay with the white pants that you see in the recording. Merlano said that the former congressman usually changes her clothes, and it is a mania that she has, “when she wants to put different clothes in jail: she does what she has to change and she takes old clothes, and she puts on clothes new". "My mother is not sorry for anything, she is getting worse in front of the one, she changes in front of the one, that never rang me or seemed strange," said the young woman in the news, when asked if that situation he had not woken up any suspect. The young woman also said in the interview that she never imagined that her mother was going to escape, let alone through the window of the dental office, because she says that she retired first from there because the fugitive today does not like to be seen in handcuffs. Aída Victoria Merlano Manzaneda Related Article Does Aida Merlano prefer to run away from justice than from those who are after her vote purchase? “I leave the building, take the elevator, under, bought a micellar water. I did not run away from the building, I left as if nothing. And when I'm at the Andean (mall) paying for clothes, someone calls me to say: ‘Did you watch the news?’. Obviously I got scared, there I entered as in ‘shock’, ”Merlano explained. The statements were delivered by Merlano Manzaneda hours after a judge ordered her to be released, along with the dentist who attended to her mother: Javier Cely, although prosecutors in the case asked to be sent to prison. Daughter of Aída Merlano Related Article Prosecutors who asked for jail for Merlano's daughter will pay with their charge for the defeat Precisely this defeat of the accusatory party led the Prosecutor to take action, as according to the attorney general in charge, Fabio Espitia, the order is to "refresh" the team of prosecutors who take the case. In a nutshell, La FM summarizes, the decision is to “remove” the prosecutors from office. Next, the video of the interview with the young woman, and another that summarizes this whole case that she had to face.

Welcome!

This week we show you a video in which Valentino Rossi was driving along his beloved ‘Panoramic’, the road near Tavullia where, as he confessed, he grew as a person and as a pilot. The motorcycle that ‘Vale’ uses in the video is its exclusive Yamaha Mya, an FJR 1300 totally modified by Rodolfo Frascoli and the design department of its VR46 merchandising company. The base had to be an FJR 1300, a motorcycle that Valentino loves, mixed with a ‘flat-tracker’. Two designs were presented to Rossi and he chose the one that merged a WR450F with the roadster. The small dome-faceplate with the R1M-style air intake is practically the only element in this area. The original chassis was used, modifying the rear, the swingarm and the position of the shock absorber anchors. A pair of small ellipsoidal headlights from an R1, as well as switches, have been incorporated on the sides. Flat-track tetracilíndrica The engine was retouched by Francesco Penati, former Gilera chief mechanic, while the exhaust system was manufactured by Akrapovic, who developed it exclusively for this motorcycle in Slovenia in the winter of 2016 and has a ‘46’ engraved on each silencer. Mount air filters of individual cartridges. The front brake system is a single disc, with a pump and caliper developed by Brembo and with MotoGP specifications. The electrical system and the tank, located under the seat (with a gasoline vacuum pump) were designed by the team led by Francesco Penati. The Öhlins inverted fork is from a Yamaha YZ450, modified by Andreani. Both spoke wheels are 19 ”and are fitted with neumáticos flat-track’ tires. The footrests and other parts were designed by Rodolfo Frascoli, while most of the rest of the components belong to the Yamaha accessories catalog.

The national coach spoke at a press conference in Spain. Carlos Queiroz, a Colombian coach, said at a press conference in Spain that he did not call James Rodríguez and Falcao García on his own decision and left behind speculation. The virtue of Colombians. They are several. Your passion for football and for the Colombian National Team. I also rescue that the players have creativity and sense of risk for the matches. I try to put order, but the virtues are very good. James and Falcao After the call I was aware of some speculation. that's normal. It must be said that we must not confuse. They are speculations that make no sense. They are two very important players in the memory of the fans. I do not like to talk about players who are not in the call. That is not respectful of those who are. James and Falcao 1. You have to separate the important from the minor. We must leave the speculation behind. You have to be more independent from Spain. I make the decisions after analyzing the players. The decisions that are made are the best for the team. I never tire of talking to my coaching staff or the players to make the best decisions. (You can also read: Colombian players talk about the position they would like to be in) James and Falcao 2. Forgive me if I don't have speculative answers. I have to speak clearly and honestly, the decision is natural in time with the observations. The ones I called are players that respond to the objectives. We seek to consolidate a basic group and always try to keep the calls to fix a cumulative effect. Barranquilla I work with very experienced players. I remember what 'Pacho' Maturana said: "When you have the ball and you don't put speed on the game, not much happens, but when you don't have the ball, the problem comes." The Colombian team has to be prepared to play. The football that I love to do I would like to do always. Changes in the call. I did not hide that Colombia should do a job on the issue of archers. Those who are, after Copa América, because the criterion is to give the opportunity to the new ones to meet them and then we will be ready to make the best decisions for the team. That also happens in the other sectors of the field. Falcao garcia. I speak with my coaches and with the coaches of the teams in which there are Colombian players. If you want to have a good team you have to know about the players. Falcao, you do not know, but I do, that since the 2014 World Cup has been in 55 percent of the calls, failed in the challenge for several reasons. Colombians do not have vacations and that has been a reason to know how to make decisions. I have the illusion of having the best players ready. So decisions are made clearly and without speculation. Calls If there is not one, there must be a better one. We did not stay to cry. We would love to have Valderrama here, but it isn't. What are we going to do Pékerman or me? The team is more than me, or a, b, c ". Chile. We have a goal ahead of us: we must improve at all points. You have to get brighter. The results speak and we must recognize and respect that against Chile they have been better than us. That is why we have to work with the humility to recognize that they have been better. You have to see the points, the qualities we have and how to improve.

The singers Shakira, Madonna, Alejandro Sanz, David Bisbal or the footballer Sergio Ramos are some of the familiar faces he has seduced with his cocktails. But there are more The jet and the best brands raffle it for their parties. With a portfolio of clients among which are the main luxury brands, such as Chanel, Hermès, Jimmy Choo, Bvlgari, Louis Vuitton, Cartier, Maserati or Land Rover, among others. And that's not all. Álvaro Vázquez - with his company Premium Mixes - has served cocktails to personalities such as Madonna, Paris Hilton, King Felipe VI, Emilio Botín or the Duchess of Alba. Álvaro Vázquez. (Photo: Olga Moreno) Álvaro Vázquez. (Photo: Olga Moreno) Álvaro Vázquez studied at the Colegio Santa María de los Rosales, the same center as King Felipe VI and attended by the princess Sofia with Princess Leonor. Later he studied ADE specialized in Finance, thinking about following the traditional family trail. But he noticed that something was missing in his life, so he decided to try his luck with Physical Activity and Sports Sciences. "The sport had always attracted my attention, but on the way I realized that the liquid state was passionate to me and I began to be interested in the world of drinking." The opportunity is called Paris He went to London and to finance his stay there, he began working at the Hilton hotels, which would change his life completely. “By pure chance I ended up addressing the topic of drinks in one of the hotels. There I learned to relate the world of luxury and drink ”. An experience that also allowed him to meet Paris Hilton: “He asked me to try the cocktail menu of our bar. It was a great honor for me. ” In 2012 already in Spain, Álvaro realizes that the concept of cocktails, as developed in London, did not exist in our country. Moment in which he decides to give life to Premium Mixes, his bartender company. “It started as something very small. Many people told me to be careful because maybe it was not the best time because of the economic crisis. My own family put their hands to my head, because I guess they imagined me working in private banking or something. But I was sure that it would work. In Spain there was no such thing, but instead there was demand. We are a country of good drinkers! ”He jokes. He was not mistaken. A week later he was called by Jimmy Choo to set up a cocktail bar and since then he has not stopped working. His heart, for Hermès (and the Duchess of Alba) Premium Mixes set up bars in practically all fashion and luxury brand parties, but also in private parties and weddings or family events. If Álvaro had to choose between one of all his VIP clients, he stays with Hermès. “Since I was little I saw how my mother took special care of one of her bags, it was as if it were her jewel. It was a great honor and a special moment that Hermès called me to serve cocktails at his parties. Álvaro Vázquez. (Photo: Olga Moreno) Álvaro Vázquez. (Photo: Olga Moreno) I was going to be able to work for that brand I admired so much since I was a child! ” It also tells how he had the opportunity to serve a cocktail to King Felipe VI. “He really liked the cocktail I served, he made a face of real satisfaction, which made me very excited. I also took the opportunity to tell him that he was a former student of his school and it was lovely. With Mrs. Letizia I was not so lucky, but everything will come… ”(Laughter). The singers Shakira, Madonna, Alejandro Sanz, David Bisbal or the footballer Sergio Ramos are some of the familiar faces that Álvaro Vázquez has seduced with his cocktails. “We were the favorite cocktails of the Duchess of Alba,” says Vázquez, who, as Vanitatis has learned, also serves cocktails for the Botín family and the entire Inditex dome. Premium Mixes is formed by a team of 14 people in administration tasks plus 70 bartenders. In the circles of the jet they are called “the boys of the braces” for their outfit and their appeal, which is closely linked to an experience around the amazing cocktails they prepare.

The investigation to former president Álvaro Uribe lasted seven hours. He answered all the questions. At five in the afternoon on Tuesday, the investigation of the former president and today senator of the Álvaro Uribe Vélez Democratic Center ended. The judicial diligence lasted seven hours. The former head of state was with his lawyer, Jaime Granados. Upon leaving he was calm and talked with several leaders of the Democratic Center. Now, the high court, who called him to answer for the crimes of bribery and procedural fraud, has the floor. The Court, however, was categorical and announced that Uribe is "formally linked to the process," which means that the case continues. Now, the Court will begin collecting evidence to make a decision on whether to file the process or if there are enough elements to bring the former president to trial. After hearing the senator today in the investigation on Tuesday, the Court must decide between these three options: A. File the investigation after considering that there are no elements to accuse Uribe. B. Continue with the process and bring the former president to trial for one or both crimes, but it would allow him to defend himself in freedom. C. Perhaps the least likely, in addition to following the process against him, the Court could order his detention. (You may be interested: 'No pressure will influence the decisions of the magistrates': Court) On Tuesday's day, however, an end point has already been set. It started very early. Although it was scheduled for 8 a.m. m., started a little earlier because Uribe got up early and arrived earlier. The first session lasted four continuous hours. There was a two-hour break for lunch and it resumed around two in the afternoon when Uribe re-entered the Courthouse to go to the Main Chamber of the Supreme Court. It transpired that Judge César Augusto Reyes Medina asked him all the questions that he had prepared in a conditioned office at the seat of the Court, in the Plaza de Bolívar. While outside protesters for and against expressed themselves with slogans, shouts or choirs. Although there were moments of tension, none had significance. On the day there were relevant events through social networks. The most significant, the declaration of the Court in which they make it clear that they respect freedom of expression but that they will not take any decision that is not attached to the law. (Also read: The investigation of former President Uribe before the Court ends) "No pressure will influence the decisions that magistrates are obliged to take in law," Álvaro Fernando García, president of the Supreme Court, said clearly. A few words that were a balm on a day that was believed could be more critical. It was not be for lowerly. The most recent antecedent to such a high dignitary was that of General Gustavo Rojas Pinilla. Although that was a political trial before Congress and was related to facts of his mandate. And one more recent was that of Ernesto Samper, being president, who rendered inquiries in the House, but the process against him did not prosper. The other fact that also had an impact on the networks was the trill of the Colombian ambassador to Washington Francisco Santos, who said that he woke up on Tuesday morning "in pain of homeland" and that is why he launched very hard darts against the Cut. A while later, he deleted it. Then this same social network was the scene of comments for and against, but just as the temperature dropped in the streets there too. Indeed, the protesters in the city center dispersed around noon before the threat of rain while the fluttering on Twitter also went down. But why was Uribe in court on Tuesday? This is an open file for witness mani[CENSORED]tion. This entails two violations of the law: bribery and procedural fraud. Allegedly, the file says, Uribe would have tried to pressure the ex-Juan Juan Monsalve to retract the accusations in which he links him with the birth of the paramilitary groups in Antioquia. Uribe has argued that he always fought those criminal gangs and that it was his government that demobilized them, between 2003 and 2006. He has also said that it was Monsalve who sought him because he wanted to retract his "false accusations." In September 2014, Álvaro Uribe denounced Senator Iván Cepeda because, according to him, he was mani[CENSORED]ting witnesses against him. In February last year, the Criminal Chamber of the Court closed the investigation against Cepeda and, contrary to what Uribe intended, considered that there were sufficient elements to issue copies against the former president for an alleged mani[CENSORED]tion of testimonies to harm Cepeda. In response, according to the file, Uribe sought to approach Juan Guillermo Monsalve to retract his accusations. On July 24 of last year, the then magistrate José Luis Barceló, of the Criminal Chamber, opened a process

Welcome!

Galatasaray has a difficult time in the Turkish championship and in the Champions League. The first month of Falcao García as a Galatasaray player was fulfilled and the news is not encouraging. The club goes through difficult times both in the Turkish league and in the Champions League. Related topics Falcao garcia Oct 05 Do James and Falcao's absences on Fifa date affect Colombia? Galatasaray Oct 05 Galatasaray missed Falcao, in a new date of the Turkish Super League Champions League Oct 01 Updated: Champions League matches, results and positions This bad moment could trigger a radical decision of the team coach, Fatih Terim, who could resign. Known as The Emperor, Terim is an icon of the Galatasaray. He has been in several stages where the club is worshiped by fans. However, in a team of such importance in Turkey there is not much waiting time: it is placed 10 of the table with 10 points and in the Champions League it has a draw and a defeat. Fatih Terim and Radamel Falcao García Fatih Terim, the Galataray coach (left) greets Falcao. Photo: Serhat Cagdas / Anadolu Agency. istock photo agency Turkish media, such as the 'Sabah', report Monday that Terim would be angry at several team leaders such as Belhanda, Feghouli, Babel and Mariano. Also, with some leaders. The media title on its website that Terim plans to resign. After goalless equality against Gençlerbirligi, the club leadership would have criticized the coach, who is characterized by his strong temper. The DT, according to Turkish media, would make his position available to step aside. According to Sporx, half Turkish, there will be a key meeting between the president of the Mustafa Cengiz club and Fatih Terim. Tense hours are lived in Galatasaray. Falcao has had very little participation with Terim. In the recent game he was not summoned, apparently for an unspecified injury. The Colombian has only one goal since his arrival at the club.

With his shell glasses and bangs he became one of Hollywood's most po[CENSORED]r characters. These are her most representative dresses October is an important month for movie theater fans. Or, more specifically, Edna Moda, the tiny character of 'The Incredibles'. Why? The answer lies in the designer she is inspired by: Edith Head. The most important dressmaker in the history of cinema was born on October 28, 121 years ago (in 1887) and died on the 24th of the same month of 37 (in 1981). Californian with shell glasses, symmetric bangs and a hairstyle to the bowl, the head of Paramount department became an essential piece to understand certain films such as 'Sabrina', 'The Indicreta Window' or 'The Twilight of the Gods'. In fact, its influence is still very present today. [READ MORE: Much more than Audrey Hepburn, 20 iconic Givenchy dresses (and her maison)] Her last name, Head, was actually that of her husband, Charles Head. Although the marriage lasted rather short, the dressmaker liked it so much what his name was that he stayed forever. Despite being a graduate in Philosophy and Letters, the costumes were her great passion. And he dedicated himself to it until, in the 40s, he entered to command the costume department of Paramount and became one more celebrity. His peculiar way of speaking, his way of dressing, his deep-rooted Catholicism and the parties he gave in his mansion were almost as important as the dresses of 1,131 movies he designed. He won 8 Oscars and was nominated 35 times. Vanitatis pays tribute to her best creations: Barbara Stanwyck in 'Memory of a Night' (1941) A dress with wide sleeves and dark color with a belt that enhanced the figure of a Stanwyck turned into a good-hearted thief in this classic directed by Mitchell Leisen. Olivia de Havilland in 'The Heiress' (1949) Head showed, with this adaptation of Henry James' novel, that he could also put his style on period dresses. The embroideries of the clothing of Olivia de Havilland (embodying the character who gave her second Oscar) remain a masterpiece. Grace Kelly in 'The indiscreet window' (1954) The presentation of Grace Kelly in Hitchcock's masterpiece remains iconic thanks to this vaporous skirt with which the designer showed that her wardrobe could define the character. In this case, that of his elitist life. Audrey Hepburn in 'Sabrina' (1954) In collaboration with Givenchy, Head designed some dresses like this that became a symbol of the career of the mythical Audrey Hepburn. Kim Novak in 'Vertigo' (1958) With or without a white coat, Hitchcock's Kim Novak was even more mysterious with this black model with which he walked through the streets of San Francisco.

The winners are the Americans William G. Kaelin Jr, Gregg L. Semenza and the English Sir Peter J. Ratcliffe. His work has paved the way for new and promising strategies against anemia, cancer and many other diseases. How cells can adapt to changes in the oxygen reserve. That has been the key finding that has led William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L. Semenza to win this year the Nobel Prize in Physiology or Medicine. The three experts identified the molecular machinery that regulates the activity of genes in response to different oxygen levels. Its discovery reveals the mechanism of one of life's most essential adaptation processes. (Read: The researcher who unearthed the history of teachers in Colombia) Thus, they established the basis for understanding how oxygen levels affect cell metabolism and physiological function. His work has also paved the way for new and promising strategies against anemia, cancer and many other diseases. Oxygen (O2) constitutes approximately one fifth of the Earth's atmosphere. Essential for animal life, it is used by mitochondria present in virtually all animal cells to convert food into useful energy. During evolution, mechanisms were developed to ensure a sufficient supply of oxygen to tissues and cells. The carotid body - adjacent to the large blood vessels on both sides of the neck - contains specialized cells that detect blood oxygen levels. Corneille Heymans, Nobel Prize in Physiology or Medicine of 1938, described how the detection of oxygen in the blood through the carotid body controls our respiratory rate by communicating directly with the brain. In addition to the rapid adaptation controlled by the carotid body to low oxygen levels (hypoxia), there are other fundamental physiological adaptations. A key physiological response to hypoxia is the increase in the levels of the hormone erythropoietin (EPO), which leads to an increase in the production of red blood cells (erythropoietin). The importance of hormonal control of erythropoiesis was already known in the early twentieth century, but the way in which this process was controlled by O2 remained a mystery. The hypoxia machinery There Gregg Semenza (New York, 1956) enters the scene, who studied the EPO gene and how it is regulated by varying levels of oxygen. Through the use of genetically modified mice, he demonstrated that specific segments of DNA located next to the EPO gene mediated the hypoxia response. Using genetically modified mice, Gregg Semenza showed that segments of DNA located next to the EPO gene mediated the hypoxia response On the other hand, Sir Peter Ratcliffe (Lancashire, United Kingdom, 1954) also analyzed the O2-dependent regulation of the EPO gene, and both groups found that the oxygen detection mechanism was present in virtually all tissues, not just cells kidney where the hormone is normally produced. These findings showed that the mechanism was general and functional in many different cell types. Semenza, who wanted to identify the cellular components that mediated this response, discovered in cultured liver cells a protein complex that binds to the identified DNA segment in an O2-dependent manner. He called this complex the hypoxia inducible factor (HIF), and thereafter they began to purify it. Thus, in 1995 Semenza published some of its key findings, including the identification of the genes encoding HIF. It was found that HIF consists of two different DNA binding proteins, the so-called transcription factors: HIF-1α and tRNA. Then the researchers were able to begin solving the puzzle, allowing them to understand what additional components were involved and how the machinery works. An unexpected partner When oxygen levels are high, cells contain very little HIF-1α. However, when oxygen levels are low, the amount of HIF-1α increases so that the EPO gene can bind and regulate, as well as other genes with DNA segments that bind to HIF. Several research groups demonstrated that HIF-1α, which normally degrades rapidly, is protected against degradation in hypoxia. At normal oxygen levels, a cellular machine called a proteasome - recognized by the 2004 Nobel Prize in Chemistry to Aaron Ciechanover, Avram Hershko and Irwin Rose - degrades HIF-1α. Under such conditions, a small peptide (ubiquitin) is added to the HIF-1α protein. Ubiquitin functions as a label for proteins destined for degradation in the proteasome, but it was not known how it bound in an oxygen dependent manner. The answer came from the hand of William G. Kaelin, Jr. (New York, 1957), a cancer expert. Almost at the same time that Semenza and Ratcliffe were studying the regulation of the EPO gene, Kaelin was investigating a hereditary syndrome, von Hippel-Lindau disease (VHL). This genetic pathology carries an increased risk of certain cancers in families with inherited VHL mutations. In this way, Kaelin showed that the VHL gene encodes a protein that prevents the appearance of tumors. The researcher also showed that cancer cells that lack a functional VHL gene express abnormally high levels of hypoxia-regulated genes; but that when the VHL gene was reintroduced into these cells, normal levels were restored. This was an important indication that von Hippel-Lindau disease was somehow involved in the control of hypoxia responses. Finding that was confirmed by the Ratcliffe group, which conclusively linked VHL with HIF-1α. Although experts had made great strides, there was still a lack of understanding how O2 levels regulate the interaction between VHL and HIF-1α. The search focused on a specific portion of the HIF-1α protein, and both Kaelin and Ratcliffe suspected that key to the detection of O2 resided somewhere in this protein complex.