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A "revolutionary" new class of cancer drug that can treat a wide range of tumours has been approved for use in Europe for the first time. Tumour-agnostic drugs do not care where the cancer is growing in the body as long as it has a specific genetic abnormality inside. UK doctors testing the drugs said they were "a really exciting thing". They said the approach had the potential to cure more patients and cut side-effects. The drug that has been approved is called larotrectinib. Charlotte Stevenson, a two-year-old from Belfast, was one of the first patients to benefit. She was diagnosed with infantile fibrosarcoma, a cancer of the body's connective tissue. She has been treated with larotrectinib as part of a clinical trial at the Royal Marsden Sutton, in London, for the past year. Her mum, Esther, said: "We knew that our options were limited [so] we decided to give it a try and are so glad that we did. "We have been able to watch Charlotte develop and grow at a rapid rate, making up for lost time in so many ways and amazing us all with her energy and enthusiasm for life. "She can now have a relatively normal life and, best of all, the drug has had an incredible impact on the tumour." Charlotte's tumour was caused by a genetic abnormality known as an NTRK gene fusion. One part of her DNA accidentally merged with another and the alteration in the blueprint for her body led to the growth of her cancer. But NTRK gene fusions are not unique to sarcomas - they also appear in some brain, kidney, thyroid and other cancers. "It is a really exciting thing, as is it works across a range of cancers. It's not confined to one," Dr Julia Chisholm, a children's cancer consultant at the Royal Marsden Hospital, told the BBC. NTRK mutations are relatively rare, but other targeted therapies are in development. 'Kinder treatments' It marks a move away from treating a "breast cancer" or "bowel cancer" or a "lung cancer" and towards precision medicine that takes advantage of the genetic make-up of each patient's tumour. Dr Chisholm told the BBC: "The beauty is it targets the abnormality. "There are a number of biochemical pathways that are common in many different tumour types. "I think this is the way things are going and this is about better outcomes, curing more patients and producing kinder treatments with reduced side-effects." The decision by European regulators does not mean it will be instantly available for patients in the UK. But earlier this year, NHS England described tumour-agnostic drugs as a "revolutionary" and "exciting new breakthrough" in cancer and said preparations were under way to ensure patients were given access to them. "The benefits for patients - in particular children - of being able to treat many different types of cancers with one drug is potentially huge, helping them to lead longer, healthier lives," NHS England chief executive Simon Stevens said at the time. Prof Charles Swanton, Cancer Research UK's chief clinician, said the drugs were "exciting". He added: "The NHS will need to ensure the right genomic testing is available across the country to identify patients who could benefit so it's good that the NHS is already thinking about how to get this to patients with cancer as soon as possible." Dr Brendon Gray, from Bayer, the drug company that developed larotrectinib, said: "As the first tumour-agnostic medicine approved in Europe, larotrectinib represents a real shift in cancer treatment."

Skoda has revealed its new Superb iV plug-in hybrid will start from £31,970 when it arrives Britain in January. The figure was revealed to journalists during the UK launch of the rest of the revised Superb range, and makes the new model £4,730 cheaper than its sibling, the Volkswagen Passat GTE. The hybrid will be launched as the Superb iV in recognition of Skoda’s new sub-brand that will be used for its bold electrification plans. The Superb iV features a 154bhp, 1.4-litre TSI petrol engine mated to a 114bhp electric motor, which sends drive to the front wheels through a six-speed DSG transmission. The peak system output is 220bhp, with 295lb ft of torque. The car will be capable of completing 34 miles of pure electric running, identical to the similar Volkswagen Passat GTE. Skoda has yet to release performance figues, but insiders suggest they will closely match the Passat, hinting at a 0-62mph time of around 7.4sec for the saloon. The brand also promises an official CO2 rating of under 40g/km A battery pack is located under the floor and ahead of the rear axle, which means a slight reduction in boot capacity – 485 litres for the saloon and 510 litres for the estate, compared with 625 and 660 for the non-hybrid versions respectively. Beyond the well-hidden charging port integrated into the front grille, there will be little to give away the PHEV's part-electric status. The infotainment system can display information on battery status and electric range and additional controls for the various powertrain modes. It will also be possible to programme the PHEV's air-con to cool the cabin before the car is needed. Prices for the rest of the range, with traditional petrol and diesel engines, start from £24,655 for the saloon and £25,975 for the estate version. The updated model has launched with a choice of two petrol and two diesel engines, and in six trim levels. Entry-level S models, offered with a 1.6-litre petrol or diesel engine, feature LED front and rear lights, and a new infotainment system featuring voice control. SE trim adds features including 17in alloy wheels, dual-zone climate control, parking sensors and adaptive cruise control. Above that, SE Technology features leather upholstery, heated seats and integrated wi-fi. SE L includes 18in alloy wheels, rear privacy glass, full matrix LED headlights and an electrically operated boot. SportLine Plus trim comes with 19in alloy wheels and black sports styling details, along with Alcantara upholstery and a three-spoke sport steering wheel. The range-topping Laurin & Klement trim features all of the kit from SE L, and adds 18in alloy wheels, ventilated front seats, heated front and reat seats, LED interior lighting, three-zone climate control, an upgraded navigation system and a Canton sound system, along with Skoda's Dynamic chassis control system. The existing Superb powertrains will be carried over for the facelifted model, with a new 2.0-litre 190bhp TSI unit added. The range-topper will be a 268bhp 2.0-litre turbocharged version - down around 8bhp from the outgoing on car due to the inclusion of a petrol paticulate filter and other emissions control systems. The redesigned Superb has gained a new-look grille, with added chrome trim between the LED rear lights. There is also a new front bumper, which stretches the length of the car by 8mm to 4869mm. The car is the first Skoda to gain full LED matrix headlights as an option, and new driver assistance features include predictive cruise control that makes use of data from road signs. Deliveries for the facelifted car begin in September. Skoda promises the PHEV will be highly competitive in its increasingly crowded part of the market, and is anticipated to constitute up to 20% of sales in the UK.

Democratic calls to impeach President Donald Trump are gathering pace after it emerged he withheld aid to Ukraine, pressing it to investigate his would-be White House challenger Joe Biden. The House of Representatives' Democratic leader, Speaker Nancy Pelosi, is meeting party members on Tuesday to consider impeachment. Mr Trump has acknowledged freezing the aid to Ukraine but denied wrongdoing. Only two US presidents have ever been impeached. What's the latest on Ukraine? At the United Nations General Assembly in New York City on Tuesday, Mr Trump said he only froze military aid to Ukraine because he wanted European countries to contribute money, too. The Republican president also acknowledged pressuring newly elected Ukrainian President Volodymyr Zelensky during a phone call on 25 July to investigate US Democratic presidential candidate Joe Biden. He told reporters "there was pressure put on, in respect to Joe Biden. What Joe Biden did for his son, that's something they should be looking at." Mr Trump's remarks came after US media reported that days before his phone call with Mr Zelensky, Mr Trump instructed his acting chief of staff, Mick Mulvaney, to withhold nearly $400m in military aid for Ukraine. But the US president insisted on Tuesday that nothing untoward happened during the "perfect call". Mr Trump and his conservative allies have pointed out that Joe Biden, while US vice-president, threatened in 2016 to withhold aid to Ukraine unless it fired a top prosecutor whose office had opened an investigation into a natural gas company where Mr Biden's son, Hunter Biden, was a board member. Other Western officials had also called for the same prosecutor to be removed for being soft on corruption. Ukraine's current prosecutor, Yuriy Lutsenko, told Bloomberg News in May he had no evidence of wrongdoing by Mr Biden or his son. Congressional Democrats are demanding a transcript of the Trump-Zelensky phone call, which the White House has declined to release. What's the latest on impeachment? On Tuesday, Speaker Nancy Pelosi, the most powerful elected Democrat, is holding a closed-door meeting with House members to consider impeaching Mr Trump. Mrs Pelosi has so far resisted calls among her liberal rank-and-file to remove the Republican president from office. On Monday night, the Washington Post published an op-ed by seven freshman Democrats - all with backgrounds in the US military and intelligence agencies - who said the "stunning" accusations against Mr Trump amounted to "a national security threat". "If these allegations are true, we believe these actions represent an impeachable offence," wrote the lawmakers. "We do not arrive at this conclusion lightly." The representatives - Gil Cisneros of California, Chrissy Houlahan of Pennsylvania, Abigail Spanberger and Elaine Luria of Virginia, Jason Crow of Colorado, Mikie Sherrill of New Jersey and Elissa Slotkin of Michigan - all serve in districts previously held by Republicans. Nearly a dozen additional Democrats have come out in favour of impeachment over the last week since the Ukraine phone call controversy came to light. More than 145 House Democrats now back such a move - more than half of the party's 235 members in the lower chamber of Congress. But impeachment currently lacks the support of most US voters. A recent opinion poll found that 59% oppose removing the president from office. Under the US Constitution, the House has the power to impeach a president for "high crimes and misdemeanours" and the Senate then holds a trial on whether to remove the president from office. But the Senate is under Republican control and is seen as highly unlikely to convict the president.

9.20.2019 By The Fortnite Team The Bat-Signal has appeared over the Island. Answer the call in this Caped Crossover from now until October 6 in celebration of Batman’s 80th anniversary! A Rift Zone has brought Gotham City to Fortnite. Of course, it wouldn’t be Gotham City if villainy didn’t come along with it. This POI lets you be the hero the citizens of Gotham City need by giving you your own Batman cape and the power of Glider Redeploy! Being a hero is even more fun when you have some “wonderful toys” at your disposal. Drop in the game now to try out the Batman Grapnel Gun and Explosive Batarang! For the details of these, head over to the v10.31 Patch Notes. One of the best parts of being a Super Hero is the suit — save the day in style with the Batman Caped Crusader Pack! In addition to other Batman-themed cosmetics, this Pack includes the Batman Comic Book Outfit and The Dark Knight Movie Outfit! The Batman Caped Crusader Pack will be in the Store until October 6. The Shop features individual Batman-themed items too, including an Outfit for his feline frenemy Catwoman! Rescue the Island from danger by taking on the heroic Challenges available until October 1. Completing these Challenges will earn you free rewards from the Welcome to Gotham City Challenge Bundle, including the Catwing Glider! (But stopping evil is reward enough, right?) Join in on the action today. Long Live The Bat, Fortnite-style.

Description Unleash your imagination and create a world of Sims that’s wholly unique. Explore and customize every detail from Sims to homes–and much more. Choose how Sims look, act, and dress. Determine how they’ll live out each day. Design and build incredible homes for every family, then decorate with your favorite furnishings and décor. Travel to different neighborhoods where you can meet other Sims and learn about their lives. Discover beautiful locations with distinctive environments, and go on spontaneous adventures. Manage the ups and downs of Sims’ everyday lives and see what happens when you play out realistic or fantastical scenarios. Tell your stories your way while developing relationships, pursuing careers and life aspirations, and immersing yourself in an extraordinary game where the possibilities are endless. Create Unique Sims – A variety of Sims are yours to shape and mold, each with distinct appearances, dynamic personalities, and inspiring aspirations. Use powerful customization features to bring your imagination to life. Create yourself, your favorite celebrities, your fantasy, or your friends! Change your Sims’ clothing to reflect your mood. Give your Sims depth and purpose with quirky traits and great ambitions. Build the Perfect Home – Design the ideal homes for your Sims using Build Mode. Construct the home of your dreams by planning the layout, choosing furnishings, and altering the landscape and terrain. You can even add a pool, basement, and garden. Hate what you’ve done with the place? Scrap it and rebuild effortlessly with new ideas and designs. Explore Vibrant Worlds – Your Sims can visit new communities to expand their social circle, hang out with friends, or throw unforgettable parties. Play with Life – Your choices shape every aspect of your Sims’ lives, from birth to adulthood. Along the way, develop skills, pursue hobbies, find your Sims’ calling, start new families, and much more. Discover a Community of Creators – Use the Gallery to find inspiration from a network of players just like you, where you can add content to your game or share your own creations. Download, like, and comment on your favorite Sims, homes, and fully designed rooms. Join the community and join the fun! System Requirements PC SYSTEM REQUIREMENTS MINIMUM SPECS: OS: Windows XP (SP3), Windows Vista (SP2), Windows 7 (SP1), Windows 8, Windows 8.1, or Windows 10 CPU: 1.8 GHz Intel Core 2 Duo, AMD Athlon 64 Dual-Core 4000+ or equivalent (For computers using built-in graphics chipsets, the game requires 2.0 GHz Intel Core 2 Duo, 2.0 GHz AMD Turion 64 X2 TL-62 or equivalent) RAM: At least 2 GB RAM HARD DRIVE: At least 14 GB of free space with at least 1 GB additional space for custom content and saved games VIDEO: 128 MB of Video RAM and support for Pixel Shader 3.0. Supported Video Cards: NVIDIA GeForce 6600 or better, ATI Radeon X1300 or better, Intel GMA X4500 or better DIRECTX: DirectX 9.0c compatible SOUND CARD: DirectX 9.0c Compatible INPUT: Keyboard and Mouse ONLINE REQUIREMENTS: Internet connection required for product activation. RECOMMENDED SPECS: OS: 64 Bit Windows 7, 8, 8.1, or 10 PROCESSOR: Intel core i5 or faster, AMD Athlon X4 VIDEO CARD: NVIDIA GTX 650 or better MEMORY: 4 GB RAM HARD DRIVE: 18 GB of Hard Drive space MAC SYSTEM REQUIREMENTS MINIMUM SPECS: The Sims 4 will *NO LONGER BE SUPPORTED* on Non-Metal Mac OS machines or PC 32-bit Operating Systems. See FAQ here. OS: Mac OS® X 10.7.5 (Lion) CPU: Intel Core 2 Duo 2.4GHz Processor or better RAM: At least 4 GB RAM HARD DRIVE: At least 14 GB of free space with at least 1 GB additional space for custom content and saved games VIDEO: NVIDIA GeForce 9600M GT, ATI Radeon HD 2600 Pro or better. Video RAM of 256MB or better INPUT: Keyboard and Mouse ONLINE REQUIREMENTS: Internet connection required for product activation. RECOMMENDED SPECS: OS: Mac OS® X 10.9 or later PROCESSOR: Intel Core i5 or better VIDEO CARD: NVIDIA GTX 650 or better MEMORY: 8GB RAM HARD DRIVE: 18 GB of Hard Drive space

sin Slayers has, much like its heroes of yore, broken me down. Stripped of joy, muttering endless repetitions of “Pray or Die!”, fighting countless meaningless battles of pure meat-sponges. I wish for release; all I want to do is finish this game so I can get off this ride to the Sin Lords of Hell. Failing in Darkest Dungeon leaves me with a better sense of gratitude than succeeding in Sin Slayers. There is only nihilism, existential dread that I must continue forward in a vain attempt to hope that things will improve as I reach further acts of the game. If only I knew. Developed by goonswarm, Sin Slayers is a tactical turn-based fantasy RPG. As previously stated, it shares a design space with games like Darkest Dungeon or soon to release MISTOVER, though devoid of any charm or personality. Assembling a group of three unique heroes from a somewhat diverse amount of options, you venture forth into the domain of various Sin Lords: Gluttony, Sloth, Greed, etc. Fighting your way through randomly generated maps, you must locate the sub-boss of each domain and slay them, then return to another randomly generated map of the same territory and hunt down the Sin Lord. Along the way, you are presented with various events including but not limited to: grave robbing, praying at altars, opening locked chests, finding side-quests, etc. Your actions throughout these events will either increase or decrease your overall Sin level. Sin levels can allow you to obtain loot faster, but also increase the strength of various enemies. It’s the fundamental system that Sin Slayers abides by, and it is completely and utterly useless. I really cannot stress this enough, this Sin meter is totally avoidable, and I would openly encourage it even. So many times, I would attempt to engage with this system, driving my Sin up to extremely high levels, thinking I would be given a new form of gameplay, new dangerous enemies, or consequences to content with. Not so, I am sad to report that all I encountered were enemies of marginal strength increases with massive piles of health. Slugging through higher Sin levels was not engaging, it was a chore. Now I see why some heroes gave into Sloth’s temptations, I wouldn’t want to deal with this every day either. It’s unfortunate because at a surface level, this game should be doing a lot of things right. It has a simple scaling combat system pertaining to a few skills, various strengths and weaknesses, and building resources over time. Heroes obtain Rage via a few different means, most often via their basic attack or ability, which then allows them to use more unique or interesting moves. Unfortunately, this can often mean piles of time spent doing average move sets to build up enough Rage to get to the more interesting bits. Likewise, once your heroes get to a certain level of skills and levels, basic fights become so rudimentary that you often don’t even employ these abilities and combos in favor of just spamming basic stuff to make fights go faster. Don’t even get me started on animation speed, which seemingly doesn’t change, even when you increase “battle movement speed” to four times the normal rate! All that changes is how fast each character zips across to hit someone, but the actual strike or cast takes it’s full normal rate of time. After you’ve seen the Priestess cast Heaven’s Judgment for the 3,000th time you just wish you could make it go faster. I sincerely hope they consider patching in an auto-battle system at some point for when you are fighting monsters that clearly bear no threat to you outside of the occasional critical hit. If I’m coming off as overly negative, it’s not out of spite or desire, I want to like this game. I’m normally a huge fan of the genre, I want others to discover it! However, when multiple core systems just aren’t melding in a cohesive way, I have no choice but to call a spade a spade. As I previously mentioned, once I just fundamentally ignored the Sin Meter, as there is little reason to engage with it at all, I was still flooded with money and resources from all of the combat encounters I navigated through. Side-quests offered little value for the amount of effort they required, and were completely devoid of any story or meaning, so eventually I just gave up on pursuing them outside of the few core game-play expanding missions. In the very first zone I was sent off to collect mushrooms for a Pigman’s stew. At first, I was elated, as I had just collected quite a few mushrooms from various encounters and events! Turns out, those “mushroom” items were not the “mushrooms” I needed for this quest, and at that point I knew I was in for a rough ride. The dialogue is often a detriment to the ambience of the game, and I often wonder if the entire atmosphere would be better off if all of the protagonists, and maybe even the Sin Lords themselves, were silent and eerie matching the attempted aesthetic of a barren run-down world. There are so many small moments where Sin Slayers wants to come across as badass, difficult, and interesting. Unfortunately, often enough the various snippets of writing or descriptions are empty of any substance or character. I don’t feel connected to this world like I have others, it feels like a self-aware copy of Diablo. Back to core systems, a recent addition to the game, the Goblin Merchant, then allowed me to simply buy my characters up to the maximum level and skills. It wasn’t a progression as much as it was flying past any semblance of accomplishment or value, because the game allowed me to do so with little fanfare or resistance. Soon enough I found myself totally disinterested in engaging with any other randomized storefronts, as the prices they charged for mundane items was completely out of touch with how cheap experience gems were by comparison. I suppose the one upside to this is that as I unlocked new heroes, it also allowed me an easy way to finalize their growth and experiment with different group compositions. I just wish there was any semblance of challenge or consequence for directly ignoring fundamental mechanics of the game. I was given more than enough weapon and armor choices through my various boss kills, and given each character can only equip up to two items, I wasn’t hampered by ignoring any optional exploration events. Very rarely, if ever, did a side quest yield something that was better than what I already had or was able to craft. As I’ve progressed through each Sin Lord’s domain, I have only had a full party wipe once thus far, and that’s because I was taking time to test out the weaknesses of the Librarian, the sub-boss of Pride’s domain, without having brought the proper party. Some bosses have, admittedly, called for a bit of challenge while I figured out their Rage attack patterns, but after a few turns of analysis it’s pretty easy to turn the tables from there. Then the monotony of slowly whittling down their health bar, often as they summon additional minions over and over, begins. Some bosses do have secondary phases where patterns completely change, or new attacks emerge, and that’s when the potential of this game shows itself. Sadly, it’s not often enough, and is an experience that I wish had more pomp and circumstance outside of just the Sin Lords. For what it’s worth, the developers are very open to feedback about the game, and have a roadmap of changes and updates they would like to implement throughout the remainder of this year. They seem like folks who want to continue to build and grow their game into something worthy of pride and praise. New challenge zones and a Hell difficulty could be the answer to my sorrowful prayers, and I genuinely wish them luck as they continue forward with development. In the interim, I will be putting Sin Slayers down for now, I suppose I should thank it for reminding me that there are other, more compelling, games in this genre that are worth my time. Hopefully the next time I pick up this title I won’t be overcome with feelings of what could have been, and can instead enjoy a romp of cutting down the wrathful lords of Sin.

> Opponent's nickname : @#Superme > Theme (must be an image): > Work Type: Avatar > Size & Texts: 150x250 & text Battle , Csblackdevil > How many votes?: 8 > Work time: 12h

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