-Sethu

How far would you go to increase your life span by 500%? One ant species engages in brutal colony-wide brawls to replace recently deceased queens — and the victor not only gains the throne, but also gets a dramatic boost to their longevity. Upon the death of a queen, Indian jumping ants (Harpegnathos saltator) battle to see which worker will take the queen's place. Winning the crown means more than pumping out eggs — it also means living 500% longer than the average worker. Now, scientists may have pinpointed how substitute queens slow their aging. The secret lies in a protein called Imp-L2, which counteracts some of the effects of insulin in the substitute queen ant's body, according to a new study, published Thursday (Sept. 1) in the journal Science. In general, the hormone insulin helps direct sugar from the circulatory system into cells, where it can be used for fuel. The substitute queens — officially known as pseudoqueens or gamergates, in reference to the Greek words for "married worker" not the misogynist online harassment campaign GamerGate — must boost their production of insulin to contend with the incredible amount of food they must consume. "If you want to make eggs, you need to have a lot of insulin because you eat constantly," co-senior author Claude Desplan, a professor of biology and neural science at New York University, told Live Science. Although necessary, this influx of insulin should theoretically come with a catch: In addition to helping shuttle sugar into cells, insulin sets off several molecular chain reactions, some of which contribute to the aging process. Specifically, the "Akt signaling pathway" — which is involved in many cellular functions, ranging from metabolism to cell survival — can be activated by insulin and has long been tied to aging and age-related disease. So, if a pseudoqueen starts pumping out huge quantities of insulin, in theory she should age more quickly than the average worker ant, who doesn't make as much of the hormone. "However, in the case of these ants, it's the exact opposite," Desplan said. The median life span of a typical worker ant is nearly eight months, while pseudoqueens can live for about three years and three months. "It's a huge extension of the life span," he said. And interestingly, if a pseudoqueen is placed in a different colony with an already-established ruler, she'll revert to being a normal worker, Desplan said. These former pseudoqueens are called "revertants" and have life spans similar to those of workers. Somehow, only queens and pseudoqueens, despite all their insulin, manage to survive for years on end. To solve this apparent paradox, Desplan teamed up with his longtime collaborator Danny Reinberg, a professor of biochemistry and molecular pharmacology at the NYU Grossman School of Medicine. Their team sampled tissues from H. saltator workers, revertants and pseudoqueens, focusing on tissues involved in metabolism and reproduction. These included the brain, ovaries, fat body, an organ similar to the human liver and adipose (fat). Using a technique called bulk RNA sequencing, the team analyzed which proteins were being built in the sampled tissues. A molecular cousin of DNA, RNA carries genetic instructions on how to build proteins, ferrying these blueprints from the cell's command center to one of the cell's protein construction sites. By peeking at these RNA instructions, the team discovered that, compared with workers and revertants, pseudoqueens produced much more insulin in the brain and began producing more fat and vitellogenin — a precursor to egg yolk — in the fat body. Some of these resources from the fat body was transported to the ovaries, to support egg production, and some of the fat went into making a unique pheromone that only queens and pseudoqueens exude. (It's the disappearance of this pheromone in a nest that prompts worker ants to duel after their queen dies.) As pseudoqueens make more insulin, their ovaries grow and develop so that they can carry eggs. The insulin directs this ovary maturation process through the "MAPK signaling pathway," another chain of chemical reactions that can be set off by insulin. At the same time, the ovaries make Imp-L2, the team discovered, which essentially blocks the Akt signaling pathway that could otherwise cause rapid aging in the pseudoqueen. Imp-L2 secreted from the ovaries also makes its way to the fat body and provides an anti-aging shield to that organ, too, the team determined. "The two main branches of the insulin signaling pathway" — MAPK and Akt — "appear to differentially regulate fertility and lifespan, with increased signaling in one aiding reproduction in pseudoqueens and decreased signaling in the other consistent with their extended longevity," Reinberg said in a statement The team's next step will be to understand how Imp-L2 blocks only the aging-related pathway and not the reproduction-related one, Desplan told Live Science. They plan to study the effects of the insulin-blocking protein in additional insects, including fruit flies, and then eventually in mammals. "We don't know exactly what's going to happen," Desplan said. "Flies and ants aren't exactly similar to one another." And it's even more difficult to predict whether the anti-aging benefits Imp-L2 grants to Indian jumping ants would carry over to noninsects, such as mammals, he said. https://www.livescience.com/secret-to-pseudoqueen-ant-longevity

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Mangte Chungneijang Mary Kom also known as MC Mary Kom is an Indian Professional boxer. And with all her achievements in her career of boxing, she has also got the nickname of Magnificent Mary. All of Mary Kom Biography is about winning awards and being the first female player or the first player to make many world level records. She is also a member of Rajya Sabha, the upper house of the Indian Parliament along with Akhil Kumar as an observer for boxing. Other than this Mary Kom is the first Indian female to win a gold medal in the Asian Games and her Images vent completely viral after this win. And also became the world number 1 in light-flyweight boxing in the rankings done by AIBA. Life as a Child Kom was born on the 1st of March 1983, in a rural district of Manipur. And her family was very poor as they were farmers. Kom lived her life as a child by helping her parents on the farms as well as at home. She was into sports from a very early age and was an athlete in her school days. Her interest in sports came from her father who himself was a wrestler in his younger days. A few years later, she shifted to Imphal the capital city of Manipur to complete her class 10th. But she failed and did not wish to reappear for exams. And further graduated from college after giving the NIOS exam. Her interest shifted towards boxing only in 2000, at the age of 17 after looking at the success of Dingko Singh. She then started training for boxing but kept it a secret from her own father. Because he believed that boxing would spoil MC Mary Kom’s face and reduce her chances of getting married. As in rural India back in the days getting married was the most important thing in a girl’s life. Her father later came to know about her love for boxing when Images of Mary Kom were printed in the newspapers. After her win at the State Boxing Championship 2000, which was her first award as a boxer. It took Mary Kom a couple of years to convince her father, but she did and he started supporting her. The Career of MC Mary Kom Kom started her journey by going step by step. She reached the International Level in the year 2001 and continued to represent her nation. But after marriage, Mary Kom was not seen in the boxing arena for a long period of time because she was busy being a mother to her Twins born in 20007. She started playing again after she had her first two kids. And has been playing ever since. She has taken time off due to injuries and personal life. But Mary Kom has never disappointed Indians and has made sure the Indian Flag remains high as always by winning medals, trophies, and Awards for India. National-Level Achievements of Kom The Biography of MC Mary Kom as an Indian Professional Boxing player only started when she started playing at the national level. She though after playing at the international level still plays in the tournaments held at the national level. She won her first Gold in 2001 as the Women Boxing Champion of India. Followed by winning the East Open Boxing Champ later in the same year. MC Mary Kom also won the title of Sr World Women Boxing Champ (WWBC) five times in her entire career out of the six she played. The winning editions were the 2nd (2001), 3rd (2003), 4th (2004), 5th (2004), 6th (2005). She lost the 10th edition in 2009 at the quarter-final stage in Jamshedpur. Mary Kom also won the National Women Sort Meet in New Delhi 2001 and also won the National Games in the year 2002 held in Hyderabad. All her achievements have become an example for the ladies from the rural part of the nation to come forward and express themselves in different fields to lead a successful life. Kom in Olympic Games Mary Kom was a part of the 2012 Olympic Games were Women’s Boxing started for the first time. She had to also change her weight category to get qualified for the Olympic Games. Except for the weight gain she also had to face a lot of obstacles, just to represent Indians in the Olympic Games. She had to travel all alone to Thailand, Bangkok for the qualifiers. Where she lost her wallet along with her passports and other necessary documents. After a selection, she was accompanied by her mother to the London Olympics. Where she became the first Indian woman to win the bronze medal in Boxing. She was also awarded cash prizes as a token of appreciation from the Government of India and her State Government. This is one of the biggest achievements of Mary Kom in her Biography. Kom in Asian Events The Biography of Mary Kom is filled with Awards and achievements in the Asian Events. Which include the Asian Championship, Asian Games, and the Asian Indoor Games. The first Asian Championship Medal came in Hisar, India. Where she won a gold medal in the Pin weight category. Further, in the Asian Women’s Championships held across the Asian countries, she kept on winning a Gold medal for her nation for the years 2005, 2010, 2012, and 2017. But in the event held in 2008 in Guwahati, India she had to settle with a Silver Medal when she lost to Jong Ok again in the pin weight category. MC Mary Kom was also part of the Asian Games both indoor and outdoors. And has made her country proud in both fields. Her first Asian Game medal came in an Indoor tournament held in Hanoi in 2009 where she won a Gold medal again in the category of pin weight. After this, she won a bronze in 2010 and a gold in 2014 in the category of a flyweight. Mary Kom in World Championships To date, MC Mary Kom has been in a winning spot eight times. Out of which two spots were for a bronze medal and a silver medal. And the rest of the times she has won 6 World Championships Titles. Starting from the year 2001, where she had to settle with a silver medal at the AIBA Women’s World Championship for the first time held at Scranton, Pennsylvania, United States of America. She secured the title of AIBA Women’s World Championship in the next edition of 2002 in Turkey. After that, she played five editions of the same World Championships and kept on defending her title as the World Championships held across the globe. The editions that she won were 2005, 2006, 2008, 2010, and 2018. In her last World Championship edition, she had to settle for a Bronze in 2019. Where she lost the semi-final to a Turkish player Buse Naz. Other than this, she has also won the Women’s World Cup once in the year 2004. And a Gold Medal at the Commonwealth Games in 2018 held in Queensland, Australia. Though her category of playing kept on changing with the change in the norms of AIBA. During the starting of her career she played under the Pin Weight category, but after its merger in 2010 where the weight categories were changed. She had to shift to the Fly Weight category. Awards Received by Mary Kom For the pride that Kom has brought to her nation. Her efforts have been appreciated by the Indian Government and have been awarded various different honors. Other than that, her efforts have also been appreciated by the different International Sports council including the AIBA (The International Boxing Association). Below is a list of all her awards. Arjuna Award for Boxing in 2003 Padma Shri in the category of sports in 2006 Rajiv Gandhi Khel Ratna Award in 2009 Padma Bhushan in the category of sports in 2013 Padma Vibhushan in the category of sports in 2020 AIBA first ‘promising boxing career’ Brand ambassador for 2016 AIBA World’s Women Boxing Championship AIBA 2008 ‘Magnificent Mary’ Sahar Sports Award ‘Sportswoman of the year 2010’ Olympians for Life by WOA https://mybestguide.com/sports/mary-kom/

Nick Movie: Black Panther: Wakanda Forever Time: 11|11|2022 Netflix / Amazon / HBO?: - Duration of the movie:/ Trailer:

Live Performance Title: Maninder Buttar - Sakhiyaan Signer Name: Maninder Buttar Live Performance Location: / Official YouTube Link: Your Opinion About the Track (Music Video):10/10

Musician Name: Ravi Shankar Birthday / Location: 07|04|1920 /British, India Main instrument: Sitar and vocal Musician Picture : Musician Awards & Nominations: Bharat Ratna, Padma Bhushan and Padma Vibhushan Best Performance: Gat Kirwana , Raga Malkuas and Tala Sawari Other Information: /

Artist: Ravi Shankar Real Name: Ravi Shankar Birth Date /Place: 07|04|1920 /British, India Age: he aged 92 on 11|12|2012 Social status (Single / Married): Married Artist Picture : Musical Genres : Classical Music Awards: Bharat Ratna, Padma Bhushan and Padma Vibhushan Top 3 Songs (Names): Gat Kirwana , Raga Malkuas and Tala Sawari Other Information: Shankar was born to a Bengali Brahmin familyIn 1956, Shankar began to tour Europe and the Americas playing Indian classical music and increased its po[CENSORED]rity there in the 1960s through teaching, performance, and his association with violinist Yehudi Menuhin and Beatles guitarist George Harrison. His influence on Harrison helped po[CENSORED]rize the use of Indian instruments in Western pop music in the latter half of the 1960s. Shankar engaged Western music by writing compositions for sitar and orchestra, and toured the world in the 1970s and 1980s. From 1986 to 1992, he served as a nominated member of Rajya Sabha, the upper chamber of the Parliament of India. He continued to perform until the end of his life.

Music Title: Naacho Naacho (Full Video) RRR Signer: Vishal Mishra and Rahul Sipligunj Release Date : 11|04|2022 Official Youtube Link: Informations About The Signer:/ Your Opinion About The Track (Music Video): 10/10

Moscow's withdrawal from Lyman represents a "significant political setback" and drew public criticism in Russia because the city is in Donetsk Oblast, a top-priority Ukraine region Russia is attempting to "liberate," the British Defense Ministry said in its latest war assessment. In a Sunday video address, President Volodymyr Zelenskyy announced Ukraine had regained full control of Lyman, which Russia had used as a transport and logistics hub. "Thank you to our militaries, our warriors," he said. Ramzan Kadyrov, leader of the southern Russian republic of Chechnya, wrote on Telegram that Russian military leader Colonel-General Alexander Lapin should be fired after Saturday's retreat. "It is not necessary to make every decision with an eye on the Western, American community," Kadyrov said in Telegram post. "Yesterday, the parade in Izium, today the flag in Lyman, and tomorrow what? Everything would be fine if it wasn't so bad." Yevgeny Prigozhin, a friend of Russian President Vladimir Putin who leads mercenaries fighting for Russia in the war, suggested Russia send some leaders "barefoot with machine guns to the front." RUSSIAN TROOPS FORCED TO RETREAT: Russia abandons annexed city as Ukraine pushes forward Latest developments: ►After Zelenskyy's announcement, a video posted online showed one Ukrainian soldier saying that Kyiv's forces had begun to target the city of Kreminna, just across the border in Luhansk in eastern Ukraine. Russian military correspondents also acknowledged Ukrainian attacks targeting Kreminna. ►The Ukrainian military said it shot down eight of Russia's Iranian-built drones, seven tanks and an ammunition warehouse on Sunday. ►German Defense Minister Christine Lambrecht pledged delivery of 16 wheeled armored howitzers produced in Slovakia to Ukraine next year. They will be produced in Slovakia and financed jointly with Denmark, Norway and Germany. ►The Russian retreat from northeast Ukraine in recent weeks has revealed evidence of widespread, routine torture of both civilians and soldiers, notably in the strategic city of Izium, an Associated Press investigation has found. Ukraine military boss grateful for American support Ukraine Gen. Valerii Zaluzhnyi, commander in chief of his nation's armed forces, said he discussed his weaponry needs Sunday with Gen. Mark Milley, chairman of the U.S. Joint Chiefs of Staff. The call came days after Congress voted to provide $12 billion to Ukraine. U.S. weaponry has been key to success Ukraine's military has gained over the past month. Zelenskyy's hometown draws Russian drone strikes The hometown of Ukraine President Volodymyr Zelenskyy was attacked by suicide drones Sunday as Russia struck back against the effective Ukrainian counteroffensive that has pushed its troops back from thousands of miles of land they had occupied for months. The southern town of Krivyi Rih came under Russian attack by a suicide drone that destroyed two stories of a school early Sunday, said Valentyn Reznichenko, governor of Ukraine’s Dnipropetrovsk region. The Ukrainian air force said Sunday that it shot down five Iranian-made drones overnight but that two others made it through air defenses. The attack came one day after Ukrainian troops forced Russian troops to withdraw from Lyman, a strategic Donbas region city located in one of four areas incorporated by Russia on Friday. "Russia staged a farce in Donbas," Zelenskyy said Sunday. "And now Ukrainian flags are flying there." NATO leader issues warnings on pipeline sabotage, nuclear war NATO Secretary-General Jens Stoltenberg said Sunday that damage to two Nord Stream gas pipelines appears to be sabotage and that "any deliberate attack on critical NATO infrastructure will be met with a firm and united response from NATO." Stoltenberg, speaking on NBC's "Meet the Press," also described nuclear war rhetoric from President Vladimir Putin as dangerous and reckless – but nothing new. "That doesn't change the fact that this is dangerous," Stoltenberg said. "That's also a reason why we have so clearly conveyed to President Putin that any use of nuclear weapons will have severe consequences for Russia ... (and) totally change the nature of the conflict." Pope Francis urges Putin to halt 'spiral of violence and death' Pope Francis on Sunday appealed to Russian President Vladimir Putin for a cease-fire, imploring him to “stop this spiral of violence and death” in Ukraine and denouncing the “absurd” risks of nuclear war. Francis uttered his strongest plea yet about the 7-month-old "horror.” The pope, speaking to a Sunday crowd at St. Peter's Square. also called on Ukrainian President Volodymyr Zelenskyy to “be open” to serious peace proposals. “How the war is going in Ukraine has become so grave, devastating and threatening that it sparks great worry,” Francis said. 9 EU countries issue statement in support of EU membership for Ukraine Leaders of nine Eastern European nations released a statement Sunday reiterating support for Ukraine membership in the European Union and saying they will "never" recognize Russia's claim to four regions of the invaded country. "We support Ukraine in its defense against Russian invasion, we demand that Russia immediately withdraw its troops from all occupied territories, and we call on all members of the Alliance to significantly increase military assistance to Ukraine," said the statement signed by Poland, Czech Republic, Estonia, Latvia, Lithuania, North Macedonia, Montenegro, Romania and Slovakia. "All those who commit crimes of aggression must be held accountable and brought to justice." https://www.usatoday.com/story/news/nation/2022/10/02/ukraine-russia-invasion-live-updates/8159396001/

Nick Movie: Vikram Vedha Time: 30|10|2022 Netflix / Amazon / HBO?: - Duration of the movie: / Trailer:

Live Performance Title: Ranveer Singh, Divine and Naezy Live Performance | Gully Boy Music Album Launch Signer Name: Divine and Naezy Live Performance Location: / Official YouTube Link: Your Opinion About the Track (Music Video):10/10

Musician Name: Jagjit Singh Birthday / Location: 01|02|1941 / Punjab,India Main instrument: Vocals , Harmonium, piano and Tabla Musician Picture : Musician Awards & Nominations: Padma Bhushan and GIMA awards Best Performance: Tumko Deka Toh,Ghazal and Dosti Jab kissise Other Information: /

Artist: Jagjit Singh Real Name: Jagjit Singh Birth Date /Place: 01|02|1941 Age: 70 Social status (Single / Married): married Artist Picture: Musical Genres: classical , devotional , bhajan and folk Awards: Padma Bhushan and GIMA awards Top 3 Songs (Names): Tumko Deka Toh,Ghazal and Dosti Jab kissise Other Information: Jagjit Singh (born Jagmohan Singh Dhiman; 8 February 1941 – 10 October 2011) was an Indian composer, singer and musician. He composed and sang in numerous languages and is credited for the revival and po[CENSORED]rity of ghazal, an Indian classical art form, by choosing poetry that was relevant to the masses and composing them in a way that laid more emphasis on the meaning of words and melody evoked by them. In terms of Indian classical music, his style of composing and gayaki (singing) is considered as Bol-pradhan, one that lays emphasis on words. He highlighted this in his music for films such as Prem Geet (1981), Arth (1982), and Saath Saath (1982), and TV serials Mirza Ghalib (1988) and Kahkashan (1991). Singh is considered to be the most successful ghazal singer and composer of all time in terms of critical acclaim and commercial success. With a career spanning five decades and many albums, the range and breadth of his work has been regarded as genre-defining.

Music Title: Om Namah Shivaya Signer: Krishna Das Release Date : 25|02|2017 Official Youtube Link: Informations About The Signer:/ Your Opinion About The Track (Music Video): 10/10

I have to tell you again and again about not to join spectator you don't listen to me and you refuse to attack while mod and this You still behave as a kid