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Researchers have found that injecting a hormone secreted by bones can help the ageing muscles become youthful as well as increase the capacity of exercise in the elderly, finds a new study. Osteocalcin — a bone hormone produced during exercise — tends to decline with age in women at the age of 30 and in men at age 50. Sponsored: Avail attractive trading plans online at Sharekhan The findings showed that during exercise in mice and humans, the level of osteocalcin in the blood increases depending on how old the organism is. Osteocalcin increased the capacity of exercise in the older mice. Also, the bone-derived hormone was found powerful enough to reconstitute — in older animals — the muscle function of young animals. “Our bones are making a hormone called osteocalcin that provides an explanation for why we can exercise,” said Gerard Karsenty, Geneticist at the Columbia University Medical Center in the US. For the study — published in the journal Cell Metabolism — the team tested mice that were genetically engineered to investigate whether osteocalcin levels were affecting exercise performance. In three-month-old adult mice, osteocalcin levels spiked approximately four times the amount that the levels in 12-month-old mice did when the rodents ran for 40 minutes on a treadmill. The three-month-old mice could run for about 1,200 meters before becoming exhausted, while the 12-month-old mice could only run half of that distance. However, when old mice — whose osteocalcin levels had naturally decreased with age — were injected with osteocalcin, their running performance matched that of the healthy three-month-old mice. The older mice were able to run about 1,200 meters before becoming exhausted. “Osteocalcin is the only known bone-derived hormone that increases exercise capacity. This may be one way to treat age-related decline in muscle function in humans,” Karsenty noted.

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While the allure of the annual Electronic Entertainment Expo remains blockbuster console and PC games, virtual reality and mobile gaming will have a bigger presence at this year's game industry gathering. It'll kick off Sunday with briefings from Electronic Arts and Bethesda Softworks and continue through Thursday at the Los Angeles Convention Center. "There are 2,000 products that are going to be shown to consumers and 130 announcements that are going to be made next week about experiences and games that no one has seen before," said Michael Gallagher, president and CEO of the Entertainment Software Association, which organizes E3. "There's tremendous momentum going into E3." The festivities will spill out onto nearby streets and venues in downtown Los Angeles with companies such as Electronic Arts, Microsoft and Sony hosting fan-centric events. The organizers of E3 are joining them for the first time with their own public event, E3 Live . Gallagher expects 20,000 fans to show up for game demonstrations and other revelry. Here's a look at other E3 prospects: SECOND WIND As has become familiar practice at E3, a litany of sequels and prequels will be on hand at the convention, including several sophomore outings. They include the stealth adventure "Dishonored 2," mech-heavy shooter "Titanfall 2," superhero mash-up "Injustice 2," hacker tale "Watch Dogs 2" and sci-fi strategy game "Halo Wars 2." There will likely be many more franchise follow-ups unveiled at publishers' splashy press conferences Sunday and Monday. NEW REALITY Following the rocky launches of the Oculus Rift and HTC Vive virtual reality systems earlier this year, the immersive medium will be on the mind—and noggins—of many of the 50,000 attendees expected at E3. Gallagher said the number of VR exhibitors has doubled since last year's expo. Sony is likely to dedicate lots of energy on hyping PlayStation VR , which works in tandem with the PlayStation 4 console and is scheduled to debut this fall. There are several titles at E3 starring unlikely protagonists, such as scrappy survivor Joule of "ReCore" and introspective android Kara of "Detroit: Become Human." A few sequels are adding new heroes to the fray. The young heir Emily Kaldwin is a grown-up assassin in "Dishonored 2," and "Watch Dogs 2" will introduce an Oakland-born hacker named Marcus Holloway. "Gears of War 4" is centered on the son of the series' hulking star Marcus Fenix. LOCATION, LOCATION, LOCATION Despite the prevalence of sequels, many publishers are touting a change of scenery at E3. "Watch Dogs 2" is swapping Chicago for San Francisco. "Battlefield 1" will ditch the military shooter series' modern-day conflicts for an epic World War I setting. The true-crime romp "Mafia III" is moving to New Orleans in the 1960s, while the tactical shooter "Tom Clancy's Ghost Recon Wildlands" will take on corruption in an open-world rendition of Bolivia. GENERATION X There could be a few new pieces of hardware dramatically unveiled at E3 press conferences and on the show floor—but probably not. Nintendo is creating a new system codenamed NX, and Sony is working on an upgraded PlayStation 4 featuring 4K resolution, but both companies have maintained that they won't show them off at E3. Meanwhile, Microsoft may be developing its own updated version of the Xbox One that could make an E3 debut.

Almost seven years ago, Mozilla announced that it would begin implementing a new multiprocess-capable version of its po[CENSORED]r browser. Now, it’s finally ready to start rolling that capability out to its users, though only slowly at first. As of this writing, Firefox’s multi-process implementation (dubbed Electrolysis, aka e10s), will roll out to a select group of beta users testing Firefox 48. If the initial testers find no problems, the feature will be enabled on more and more systems, until it debuts in Firefox 48 in roughly six weeks. Here’s how Mozilla describes its own feature implementation. Similar to how chemists can use the technique called electrolysis to split water into hydrogen and oxygen, we’re using project Electrolysis to split Firefox into a UI process and a content process. Splitting UI from content means that when a web page is devouring your computer’s processor, your tabs and buttons and menus won’t lock up too… This is a huge change for Firefox, the largest we’ve ever shipped… As noted earlier, this is just the first phase. Next up we’ll be working to get E10S to the cohorts not eligible in Firefox 48. We want 100% of our release users to benefit from this massive improvement. After that, we’ll be working on support for multiple content processes. With that foundation in place, the next projects are sandboxing for security, and isolating extensions into their own processes. Adding multi-processing Chrome, Internet Explorer, and Edge have all used multi-process sandboxing for tabs for years. In this model, each browser tab is independent from the other. The upside to this approach is that a single slow-running tab can’t lock up the entire system, and it allows each tab to be independently sandboxed from the others. One of the downsides is that this requires more memory on a per-tab basis, which is why Chrome has sometimes been criticized for being a RAM hog. Unfortunately, Firefox wasn’t designed to implement each tab as its own independent process, and adding this capability required the team to rearchitect significant chunks of the browser to be compatible with this new approach. Electrolysis won’t implement multi-process support in a single leap — instead, all pages will exist in one thread, while the UI is spun off to a different thread. This should still alleviate some of the stutters and slowdowns you see from FF when the browser has many tabs open. Whether or not it completely alleviates the problem is still an open question; I regularly see Firefox’s RAM usage balloon up to 2-4GB, only to collapse back down to 1/10 that size when I open and close the browser. (Turning off all add-ons and running in Safe Mode doesn’t fix the issue.) The long-term goal of Electrolysis is still to create a browser with per-tab isolation, but it’s not clear when Mozilla will hit that target. Development on Electrolysis stopped for several years, while the company attacked other low-hanging fruit to improve responsiveness and performance, but the need to rebuild the browser from the ground up has also delayed the rollout. Electrolysis should be faster and more responsive once FF48 debuts, but whether it’ll help stem Mozilla’s market share decline is another question altogether. Data from Statcounter shows that Firefox’s market share has been trending downwards, as has IE/Edge. While the decline looks modest over just the last few months, Firefox has been slowly bleeding market share for years — according to Statcounter, its June 2014 market share was 19.6%, compared with just 15.6% this April. IE and Edge have also been dropping off, despite Microsoft’s efforts to push users towards Windows 10.

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WASHINGTON – Republican Donald Trump plans Monday to further address the deadliest shooting in modern U.S. history in a campaign speech originally intended to attack the presumptive Democratic nominee, Hillary Clinton. The switch comes a day after Trump called for Clinton to drop out of the race for president if she didn't use the words "radical Islam" to describe the Florida nightclub massacre. Trump had planned to deliver remarks Monday outlining his case against Clinton's potential presidency, but will instead retool his focus to "further address this terrorist attack, immigration and national security," his campaign said Sunday. A gunman wielding an assault-style rifle and handgun opened fire inside a crowded gay nightclub in Orlando early Sunday, killing at least 50 people before dying in a gunfight with police. Another 53 people were hospitalized, most in critical condition. Authorities identified the shooter as Omar Mateen, a 29-year-old U.S. citizen from Fort Pierce, Florida. Trump's hardline approach to fighting Islamic terrorism was a hallmark of his primary campaign. The presumptive GOP nominee has proposed temporarily barring foreign Muslims from entering the country and advocated using waterboarding and other harsh interrogation methods to try to stave off [CENSORED]ure attacks. In the hours after the Orlando shooting, Trump issued a statement calling on President Barack Obama to resign for refusing "to even say the words 'radical Islam'" in his response to the attack. He said Clinton should exit the presidential race if she does the same. In an address from the White House, Obama called the tragedy an act of terror and hate. He did not talk about religious extremists. He said the FBI would investigate the shootings in the gay nightclub as terrorism, but added the gunman's motivations were unclear. Like Obama, Clinton called the shootings acts of terror and hate, but did not use the words radical Islam in a statement released by her campaign. Instead, she said the country must "redouble our efforts" to defend the country, including "defeating international terror groups, working with allies and partners to go after them wherever they are, countering their attempts to recruit people here and everywhere, and hardening our defenses at home." Hours after Obama spoke, a law enforcement official confirmed to The Associated Press that Mateen made a 911 call from the club during which he professed allegiance to the leader of the Islamic State group, Abu Bakr al-Baghdadi. The official was familiar with the investigation but not authorized to discuss the matter publicly and spoke on condition of anonymity. While some Republican leaders have encouraged Trump to abandon his proposed Muslim ban in an effort to broaden his support among voters before November's general election, the Orlando attack appeared Sunday to harden the billionaire businessman's position. "What has happened in Orlando is just the beginning," Trump tweeted Sunday. "Our leadership is weak and ineffective. I called it and asked for the ban. Must be tough." It was one of several tweets that drew criticism online for their told-you-so tone. "Appreciate the congrats for being right on radical Islamic terrorism, I don't want congrats, I want toughness & vigilance. We must be smart!" he'd written earlier. Clinton's statement and tweets on Sunday made no mention of Trump. She did make the case for gun control and reached out to a key constituency — gays and lesbians. "To the LGBT community: please know that you have millions of allies across our country. I am one of them," she said. On Friday, Trump accused Clinton of failing to understand the gravity of the risk posed by Syrian refugees in a speech to a conservative Christian group. "Hillary will bring hundreds of thousands of refugees, many of whom have hostile beliefs about people of different faiths and values and some of whom absolutely and openly support terrorism in our country," he said. "We don't need that. ... We have enough problems right now." Clinton has said she would support allowing more refugees from the war-torn Middle East to come to the U.S., so long as they are carefully screened and vetted. Trump will deliver his speech at Saint Anselm College in Manchester, New Hampshire, a possible battleground state, which delivered Trump his first primary win. He canceled a rally planned for Monday night in nearby Portsmouth. Clinton's campaign postponed what would have been her first joint event with Obama in Green Bay, Wisconsin, on Wednesday because of the shooting. She will campaign Monday in Ohio.

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Everybody loves something for nothing. That’s what Toyota is giving to the people who buy a 2017 Camry—a slew of additional equipment for last year’s price. A smattering of additional electronics hits the mid- and up-level Camry XSE (four-cylinder model) and XLE, as well as the Camry XLE hybrid. All three get Qi wireless phone charging; the XSE and XLE further add Toyota’s Entune infotainment display with navigation and a JBL audio system. Comparison Test: 2016 Chevrolet Malibu vs. 2016 Honda Accord, 2016 Mazda 6, 2016 Toyota Camry Turbo Fours Coming to Toyota Camry, Honda Accord Toyota Camry Research: Full Pricing, Specs, Reviews, and More The starting price of all Camrys remains the same for 2017. The base four-cylinder LE still starts at $23,905 with the SE ringing in at $24,675; the upgraded XSE and XLE both demand the same $27,145 as before. (Adding the V-6 to the latter two models again will cost you another $5060.) The hybrid’s entry-level LE trim is $27,625, the SE is $28,830, and the XLE’s ticket remains $30,975.

If your favourite novels are stealing that precious sleep time from you, don’t be surprised if you have to start squeezing into your skinny jeans. A new study from the Northwestern University suggests that among healthy adults with habitual sleep duration of at least 6.5 hours, late sleep timing was associated with higher fast food consumption and lower vegetable intake — particularly among men — as well as lower physical activity. Results show that late sleep timing is associated with lower body mass index and is not associated with total caloric intake. However, it remains associated with poorer diet quality and vegetable and dairy intake. Sponsored: Avail attractive trading plans online at Sharekhan “Our results help us further understand how sleep timing in addition to duration may affect obesity risk,” said principal investigator Kelly Glazer Baron, adding “It is possible that poor dietary behaviours may predispose individuals with late sleep to increased risk of weight gain.” The study group consisted of 96 healthy adults between the ages of 18 and 50 years with sleep duration of 6.5 hours or more. The study involved 7 days of wrist actigraphy to measure sleep, food diaries to measure caloric intake and dietary patterns and SenseWear arm band monitoring to measure physical activity. Dim light melatonin onset was evaluated in the clinical research unit. Body fat was evaluated using dual axis absorptiometry (DXA). Data were analyzed using correlation and regression analyses controlling for age, sex, sleep duration and sleep efficiency. The research appeared in the journal Sleep.

There are much works better than your , and why members should vote for you and not for they ? Becuase u told they vote for me , anyway waiting for Organizer what he will say about this

Participants are not allowed to publish their work until contest ends. And about this Show all the chat no only that , i am telling the truth , your work is bad , this is my chooise <12:27:40> "Titan ;x": yes i see you have 17 votes and others 3-4 <12:27:54> "The Tiger": all vote for me <12:27:59> "Titan ;x": ajahaha your work is bad

Hello One member "The Tiger" is asking members to vote his work in BOTM , he ask me in PM to vote his work , look the chat bellow <12:16:50> "The Tiger": titan <12:16:55> "The Tiger": can vote for me here <12:16:56> "The Tiger": http://csblackdevil.com/forums/index.php?/topic/200744-csbd-botm-2-voting-time/#comment-1249240 <12:16:58> "Titan ;x": no <12:16:58> "The Tiger": im V3 <12:16:59> "The Tiger": <12:17:01> "The Tiger": ok <12:17:07> "The Tiger": np

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Our body language plays a big role in our professional success. However, it is one of the most underleveraged tools of building a confident personality. People often misuse rather abuse their physiology and wonder why they feel so low on energy during the day. Tony Robbins aptly explained this concept in one of his books: “If emotions can lead to motion, then motion can also lead to emotion.” What if I promise a success recipe to you through this article? A recipe if prepared correctly can make you more confident, motivated and creative at work. The recipe is called the ‘power-posture’ recipe and the good news is that it is absolutely free. It can be used by anyone who is willing to learn to use it. And the best part is that it needs little or no coaching. You may be doing fine at your work with your existing postures, but you have no idea what a powerful transformation you are missing on by being indifferent. Ever wondered why we feel so exhausted even when we have not used our bodies much at the workplace. The secret lies in the posture and the movement of your body. Here are five benefits of taking charge of your body language: 1. Emotional mastery is impossible without physiology: To be successful at work, you need to feel energetic and confident. Most of the people work with a slouched posture; eyes fixated on the laptop screen and staying seated for 8-10 hours every day; shoulders drooping and necks bowed. The fastest way to change your physiology is to observe it. You analyse office situations differently when you feel in-charge of the situation, in comparison to the time when you feel weak. You respond to situations rather than reacting to them. 2. Change your body language to get noticed: It is easy to spot confident people at the workplace. They hold their heads high, shoulders are upright and they carry themselves confidently. Notice the most powerful people in your office and start observing their body language. Never work in a slouched or lying posture. How they use their hands, eyes and what is the stance they take while communicating? Learn, observe and then mirror the same actions. You will make more friends at work by being open and confident than if you’re being closed and fearful. I have seen introverts transforming into extroverts by leveraging the right body language. 3. Overcome nervousness and depression: If before any presentation or client meeting you feel nervous, try a few power poses. Some of the power poses are raised hands in victory signal, hands on your waist, hands behind your head in a relaxed manner and double high-fives. Two minutes of power posing every day can improve your endorphin levels and make you feel better. I encourage all my students and workshop participants to indulge in power-posing after every hour. Some of them experience marvellous changes in their thought process as a result of power posing. Read all the Working It Out columns here. 4. Use power postures to manage stress: A relaxed body can never feel stressed. Take short walks in your office and do not sit on your chair for more than 30 minutes at a stretch. Take phone calls while walking around in your cabin, cubicle or corridor, but make sure your movement is not restricted. Power-postures are also known to lower stress-inducing hormones like oxytocin and cortisol in our body. Less stress means lesser burnouts. You can work for longer hours and feel charged up rather than drained at the end of your work-days. 5. Communication improves with body language: Studies suggest that only 7 per cent of the communication takes place through words, 33 per cent through tonality, while over 60 per cent of communication happens through our body. What language does your body speak at the office? Do you feel on top of things or burdened with work pressure? Notice the best communicators at your workplace and you will find how carefully these people choose their body language. One client or team presentation nicely given can do wonders to your career. Thus, do not take this skill lightly. Record yourself while delivering presentations and try to improve your body language with every speech. People feel less energetic not because they use their body too much, but because they use it too little or in a wrong manner. Start by observing yourself and by introducing daily routines of power-posing in your workplace regime. You will love yourself for the energy you will experience by practicing empowering postures.

Picture the auto industry as The Jungle Book, and you could cast Volvo as Mowgli. A scrappy player abandoned by Ford that reappeared in the Chinese wilderness, Volvo had to burn most of its lineup to the ground—C30, C70, S80, S40, V50, V70—before it could walk out reborn and acclaimed by luxury-minded consumers. The 40-series cars have been dead in America since 2011, although a V40 hatchback has continued trolling around in Europe since. What we have now is the [CENSORED]ure 40-series foretold in a compact crossover dubbed Concept 40.1 (and a compact notchback sedan called the Concept 40.2, which we’ve covered separately). Their names may sound as scintillating as a Firefox browser update, but this striking pair represents a set of lightly disguised production cars scheduled to enter production during the 2017 calendar year. The 40.1 is Volvo’s first application of its all-new Compact Modular Architecture (CMA), a separate chassis for lighter, smaller cars that’s distinct from the Scalable Product Architecture (SPA) underpinning the XC90, S90, V90, and next-generation S60/V60. Essentially, what you see in the 40.1 is what we’ll get in the XC40. Exact specs aren’t out, and the interior is just a mockup, but Volvo says the production model will include the “world’s most advanced standard package of safety features”; the company’s recently introduced, portrait-oriented Sensus infotainment system; and the light-colored matte wood and brushed metal that Scandinavian architects can’t live without. Semi-autonomous driving, which Volvo calls Pilot Assist, also will be offered, as will a digital-key app that can allow anyone the owner chooses to remotely unlock and start the car without using a physical fob. The 40.1 shares design cues with the handsome XC90, including its swept-back roof, Thor’s Hammer LED running lights, and waterfall-style taillights. But this smaller model’s liftgate is more steeply raked, and the beltline heads sharply north ahead of the rear fenders, which are visually connected by U-shaped creases along the entire door panels. Propped up on its suspension and with black plastic cladding wrapping short overhangs, the 40.1 looks even more trail-ready than an XC90 switched to its off-road ride height (as if you ever see Volvos driven on a trail). Part of the tall stance has to do with Volvo chief designer Thomas Ingenlath’s insistence on “wheel size to body proportion,” which allows a small car to fit big, trendy rims without absurd fender add-ons. Several powertrains will be offered across the 40-series. A 1.5-liter turbocharged three-cylinder engine, an unspecified turbocharged four-cylinder, and a plug-in hybrid that Volvo confusingly labels as “Twin Engine T5” all will be available. Various diesels will serve overseas but aren’t destined for the U.S. As we’ve reported, the three-cylinder engine should make close to 200 horsepower all by itself, fitted to a six-speed manual or automatic transmission (the current eight-speed can’t fit in this platform, and don’t count on a stick headed here). Volvo says the Twin Engine T5 powertrain’s 9.7-kWh lithium-ion battery and 74-hp electric motor will supplement the inline-three and send roughly 250 combined horsepower through an all-new seven-speed dual-clutch automatic. As in the XC90 T8, the hybrid battery is mounted longitudinally in the central tunnel in place of a rear driveshaft. All-wheel drive, granted by a second rear-mounted electric motor, may be optional. Adding the dual-clutch transmission to the hybrid makes for a complex beast. The electric drive motor is tied to the transmission’s output shaft aft of the clutch but also connects directly to the even-numbered ratios through a separate set of gears. In reverse, second, fourth, and sixth, the motor helps drive the gears on that shaft, while in the remaining, odd-numbered ratios it applies power to the output shaft. This electric supplement is available all the time. Volvo promises up to 31 miles of all-electric range, although we’re not yet certain how this setup will dramatically improve performance or efficiency compared with other plug-in hybrid powertrains (BMW, for example, uses a conventional automatic that connects to the electric motor at its input shaft). An all-electric model will be reserved for what becomes of the Concept 40.2. Volvo needs the EV and hybrid versions to sell like hotcakes if it really expects to sell one million plug-ins by 2025, a goal we still don’t find plausible given the company’s current and projected sales. But if these new 40-series cars look and drive as well as the XC90, the company stands to accelerate its upward trajectory.

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The Welsh manufacturer intends to built a four-seater saloon and a light commercial vehicle to compliment the two-seater Rasa After handing a UK debut to its Rasa at the London Motor Show, UK-based company Riversimple plans to bring two more hydrogen-fuelled vehicles to market in the [CENSORED]ure, in a bid to help normalise the high-tech hydrogen fuel. While the Rasa is a bare-bones two seater, the company has shown off pictures of a concept four-seater and a small van. Both cars use the same simple design language as the Rasa but bring their own unique styling cues, thanks to designer Chris Reitz, who also penned the Fiat 500. The four-seater saloon is sleek and [CENSORED]uristic, with a cut-off Kammback profile to boost efficiency. Standard doors would be far too boring, of course, so instead, the car features front and rear scissor doors which open in opposite directions. Covered rear wheels and bold, high-set taillights complete the space-age look. The other offering is altogether more utilitarian, but Riversimple has thrown out the styling rulebook for commercial vehicles to create a really striking van design. A stepped window line, blunt nose, and interesting quarterlight on the roof all add to the [CENSORED]uristic appeal, but the overall body shape is still square and practical, and could be ideal for smaller businesses needing transportation in and around cities. Image 5 of 5 Underneath, it looks like both hydrogen-powered vehicles would be based on the same platform as the Rasa, so we’d expect that car’s 300-mile range to drop slightly due to the added weight – unless designers take advantage of the extra space on offer to fit a larger hydrogen tank. Beta testing of the Riversimple Rasa is set to begin later this year, but it’s great to see the company continuing to look forward.

When you think of building your immunity, the first thing you think of is good old Vitamin C. While most people pop Vitamin C tablets, some supplement their diet with orange juice, lemon or aamla juice. Generally, there has been a strong belief that Vitamin C protects against colds and diseases. Two time Nobel Laureate Dr Linus Pauling claimed in 1970s that the deficiency of Vitamin C is the main cause for heart disease and many other degenerative diseases that can shorten our life expectancy. He advocated 5-10 grams (5,000-10,000 mg) of Vitamin C every day. The daily recommended intake (DRI) continues to be 40-60 mg/day for the normal po[CENSORED]tion and cigarette smokers are recommended to consume 80-100 mg/day. Subsequently, this advocacy led thousands of people to take large doses of Vitamin C. Easy availability of Vitamin C in pill form, the publication of books recommending Vitamin C as a “nutraceutical” treatment to prevent and cure colds and cancer, and the belief that it is safe and non-toxic, all contributed to its wonder vitamin status. Do higher doses really offer protection and how much Vitamin C is safe? Vitamin C with antioxidant benefits helps maintain the connective tissue protein collagen, boosts immune function, protects against infection, and facilitates iron absorption. When people dose themselves with supplements, they leave the realm of nutrition and enter that of pharmacology. Like drugs, large doses of nutrients can have medicinal effects on the body and can present serious side effects as well. The theory — that Vitamin C prevents or cures cold or cancer — is not well supported by research, since Dr Linus Pauling suggested it. Claims that a daily intake of 1,000 mg or more of Vitamin C will protect against, or cure, the common cold have never been substantiated; while taking supplements may lead to lessening of the symptoms and their duration, it cannot actually prevent people from catching a cold. Regularly, consuming more than 1-2 grams of Vitamin C daily can cause stomach inflammation, diarrhea. It must be remembered that large doses of Vitamin C escape the body in stool or urine. The body is totally saturated at intake of 150 mg/day. High Vitamin C doses may be hazardous. Regularly consuming more than 1-2 grams of Vitamin C/day may enhance iron absorption but at the same time, it may cause stomach inflammation, diarrhea, gastro-intestinal discomfort, malabsorption, abdominal cramps, excessive gas and lower vitamin B12 absorption. Other hazards of excess Vitamin C, when taken at 2 grams/day, include altering insulin response to carbohydrate in people with otherwise normal glucose tolerances, formation of kidney stones, alteration of acid-base balance, interference with the action of Vitamin E. Large amounts of Vitamin C excreted in urine can alter the results of urinary glucose tests used to detect diabetes, giving a false positive result in some instances and a false negative result in others. Vitamin C in amounts over 250 mgs can produce false negative results on tests for occult blood in the stools, masking the presence of potentially dangerous medical conditions like colon cancer. Vitamin C supplements in any dosage may be dangerous for people with an overload of iron in the blood because Vitamin C increases iron absorption from the intestine and releases iron from the storage. In addition, several instances of interference with medical regimens are also known. Vitamin C interferes with the effectiveness of amphetamines, blood thinning drugs, and tricyclic antidepressants. People taking medications to prevent blood clotting may unwittingly undo the effect if they take massive doses of Vitamin C. Therefore, people must tell their doctors before undergoing any diagnostic laboratory tests. They should also avoid abruptly quitting daily supplementation of 500 mg or more, as it may cause short term scurvy like symptoms and temporarily lowered resistance to infections. The published research on large doses of Vitamin C reveals few instances in which consuming more than 100-300 mg/ day is beneficial. Adults may not be taking major risks if they dose themselves with a gram a day, but doses approaching 10 grams can be expected to be unsafe. Most people who do not exceed this will avoid diarrhea and other gastro-intestinal problems associated with consuming excessive amounts of this vitamin. People who venture outside these limits do so at their own risk. Chewable Vitamin C can erode dental enamel, may interfere with copper metabolism and increase the risk for gout in individuals who are generally susceptible. High Vitamin C doses may be hazardous. Ample Vitamin C obtained from foods such as aamla, citrus fruits, grapefruit, strawberries, guavas, kiwis, black currants, peppers, chillies, broccoli etc is generallysafe. A glass of orange juice or 1 medium guava alone gives nearly 125 mgs of Vitamin C. Considerable amounts of Vitamin C are lost during processing and cooking. So, the next time you think of immunity building or preventing the flu or pop in mega doses enthusiastically, remember the principle of balance. Too much of a good thing can be harmful. Individuals who are prone to gout or kidney stones, pregnant women and those on medication should supplement with Vitamin C only under supervision. Also, supplements are no match to natural sources, along with a balanced diet.

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V1 - effect I was going vote v2 but i dont like gif