MERNIZ

Also: the game is coming to Steam this week after a period of Epic exclusivity. After a year of Epic Games Store exclusivity, Mortal Shell hits Steam on August 18. That’s a day before the release of The Virtuous Cycle, a big new expansion for Mortal Shell which adds a roguelike mode, a new playable shell (the game’s take on classes) and a new transforming weapon reminiscent of Bloodborne’s trick weapons. The expansion sounds promising, and if you own the game there’s no reason not to check it out: It’ll be free to keep from August 18-22. That means if you buy Mortal Shell, you’ll be able to ‘get’ the DLC pack on Steam free of charge. The offer applies to all available platforms, which presumably includes the Epic Games Store for players who already own it there. The roguelike mode features all the trappings you’d expect: the world is randomized, there are upgrade pillars dotted throughout the map, and there are “more than 100 upgrades” ranging exotic weapons through to “entirely new maneuvers.” The new shell is Hadern, which comes bearing talents including dagger mastery. Mortal Shell is among the better Soulslikes, scoring an 80 in our review. “Enjoyably tough and esoteric, if a little uneven, Mortal Shell is a decent debut from Cold Symmetry,” Rick Lane wrote.

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yes @The GodFather

nu 1522

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10 king

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Researchers were able to 'switch off' the genes behind the insect's famously long legs. Scientists have created "daddy shortlegs," a stunted version of the common household pest daddy longlegs, by suppressing the genes behind the arachnid's famously elongated limbs. Daddy longlegs, also known as harvestmen or crane flies, belong to the class Arachnids — a group of eight-legged invertebrates that includes spiders, scorpions, ticks, mites and horseshoe crabs. There are more than 6,500 species of daddy longlegs in the order Opiliones, each of which is characterized by flexible legs that are several times longer than the individual's body. In a series of new experiments, a team of researchers mapped the entire genome of Phalangium opilio, the most common species of daddy longlegs, and isolated the genes responsible for their famous long legs. The researchers then turned off the long leg genes in developing embryos, creating individual arachnids with shorter, deformed legs. Our purpose was not just to shorten their legs just for the sake of it," lead author Guilherme Gainett, a graduate student at the University of Wisconsin-Madison, told Live Science. "We wanted to understand more about how these fascinating creatures evolved their alien way of locomotion and body plan." Unlike true spiders, daddy longlegs don't use all eight of their legs for walking; instead, they use three pairs for locomotion and the remaining, and longest, pair, they wave around to feel their way around, Gainett added. Mapping the genome The researchers took two years to map all 580 million base pairs of the P. opilio genome, which is around one-sixth the size of the human genome, Gainett said. Once that was done, researchers searched the DNA map for genes likely to cause long legs, by comparing the P. opilio genome with the genomes of other insects, such as the fruit fly (Drosophila melanogaster), in which scientists had already figured out which genes code for legs, Gainett said. The comparison revealed two Hox genes — a group of related genes that code for specific body parts during embryonic development — known as Deformed (Dfd) and Sex combs reduced (Scr), that were tied to leg development in other species. Switching off the genes The researchers were confident that the Dfd and Scr genes played a role in the development of long legs in P. opilio. But it was not clear if both needed to be turned off, or if some combination was sufficient, to change leg shape and size, Gainett said. Therefore, the researchers down-regulated these genes in developing embryos to see if the change would interfere with the development of their long legs. To do this they used a process known as RNA interference, which is inspired by a process living cells use to ward off viruses. When viruses invade cells, a protein structure known as the RISC complex identifies the invaders' double-stranded RNA. The cell can then target and turn off the corresponding messenger RNA (mRNA), single-stranded RNA used to help transcribe or read genes, which viruses use to reproduce within the cell, Gainett said. However, organisms also produce mRNA to create new proteins. So the scientists repurposed the RISC complex to silence the mRNA of the Dfd and Scr by disguising those genes as viruses. "By synthesizing artificial double-stranded RNA matching your gene of interest and injecting it into the embryo, it is possible to interfere with the expression of that gene," Gainett said. Deformed legs Switching off both the Dfd and Scr genes resulted in individuals with three pairs of shortened "walking" legs. They also changed shape. "When the Hox genes are down-regulated these leg appendages transform into short food-mani[CENSORED]ting appendages called pedipalps," Gainett said. In addition to being much shorter than their normal legs, pedipalps have six segments, instead of the usual seven in regular legs; pedipalps also lack special joints known as tarsomeres, which give their legs the flexibility needed to properly move around and help sense the world around them, Gainett said. However, not all the embryos' legs became shorter. The fourth pair of legs still grew to their usual length. "This is because the fourth pair of legs likely requires the input of a third Hox gene to set up their fate," Gainett said. "This is something that we are currently investigating," he added. Some of the deformed embryos hatched with their shortened legs, but they all died before reaching adulthood, Gainett said. Understanding arachnids The findings help shine light on one of the most unusual body plans in the animal kingdom, Gainett said. "They [daddy longlegs] have been around for far longer than we have, around 400 million years, and to me, it is just amazing that we can make inferences about how animal morphologies evolved long ago and understand a bit more about the creatures we share our planet with," he added. Gainett hopes that the findings could also lead to breakthroughs in understanding other arachnid body parts. think future studies have the potential to clarify how other unique structures of arachnids are formed, such as the chelicera [fangs in spiders]," Gainett said. The study was published online Aug. 4 in

https://www.bbc.com/news Rescue workers are rushing to locate survivors of the deadly earthquake that struck Haiti on Saturday as a tropical storm hit the Caribbean nation. At least 1,419 people are known to have died in the 7.2-magnitude quake. More than 6,900 were injured, and an unknown number are still missing. Tropical Depression Grace is expected to dump up to 25cm (10 inches) of rainfall over the worst affected area. It is feared the deluge could trigger landslides. Social media footage showed heavy rain pouring over the island's east, with the quake-hit west next in its path. Roads already made impassable by the quake could be further damaged by the rains, so aid teams are racing to get essential provisions to the quake-hit region. On Twitter, Haiti's civil protection agency urged "good neighbours whose space has not been affected" to help shelter displaced people. Search and rescue teams have been arriving from the United States and Chile, with more on the way from Mexico. Cuban medical teams are already in Haiti and helping people. Humanitarian organisations say survivors need drinking water and shelter. More than 30,000 families have reportedly been left homeless. Homes, churches and schools were among buildings flattened in the quake. Some hospitals were left overwhelmed and in need of supplies as they struggled to treat the injured. The earthquake compounds problems facing the impoverished nation, which is already reeling from a political crisis following the assassination of its president last month. The south-west of Haiti appears to have suffered the worst of the damage, especially around the city of Les Cayes.

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