It is intended to be one more tool to combat the opioid death crisis that is plaguing the United States. The US Food and Drug Administration (FDA) gave the green light on Wednesday for the over-the-counter sale of Narcan, the main version of naloxone, an overdose reversal drug. "Today's approval of the over-the-counter naloxone nasal spray will help improve access, increase the number of places where it is available, and help reduce opioid overdose deaths across the country. We encourage the manufacturer to make the accessibility to the product a priority, making it available as soon as possible and at an affordable price," the agency said in a statement. More than 100,000 people die each year in the United States from overdoses, 80,000 of them from opioid use, according to the most recent data from the National Center for Health Statistics (NCHS), a number that has increased in 850% in two decades. Opioids are compounds that are often prescribed to treat pain. Although highly addictive, they are commonly used, and their use for non-therapeutic purposes is also widespread, due to the feeling of euphoria they cause. As policymakers debate and strategize to curb growing opioid addiction, they are also embracing measures to—as it is called in medical jargon—"harm mitigation." And the decision of this Wednesday of the FDA is framed in the latter. nasal spray Naloxone is a generic drug that the National Institute on Drug Abuse defines as an "opioid antagonist," and Narcan is its best-known version and is sold as a nasal spray. For it to take effect, you just have to insert it into your nose and press. Although the health authorities instruct that it always be done while calling the emergency services. https://www.bbc.com/mundo/noticias-internacional-65118695

Donald Trump is holed up in Florida ahead of his impending arrest on charges stemming from an investigation into a $130,000 payment to former porn actress Stormy Daniels in 2016. After a grand jury in New York voted Thursday to indict him, he will be the first former US president to face criminal charges. Here are some key questions about the case and what's next in the coming days. What is Trump accused of? In 2016, adult film star Stormy Daniels contacted some media outlets and offered to tell them about an extramarital affair she claimed to have had with Trump in 2006. But the then-presidential candidate's legal team found out, and his lawyer, Michael Cohen, paid Daniels $130,000 to keep quiet on the matter. This is not illegal. However, Trump's disbursement to Cohen was recorded as legal fees in the Trump Organization's accounting. And prosecutors say this amounts to Trump's falsifying business records, which is considered a misdemeanor in New York but becomes a criminal offense if it is proven that he was instrumental in the commission of another crime. Thus, prosecutors could also argue that this violates election law, because his attempt to conceal his payments to Daniels was motivated by not wanting voters to know that he had an affair with the woman. Even those who favor impeachment of Trump acknowledge that this is not a clear cut case anyway. To begin with, it has few provenances. And previous attempts to accuse politicians of crossing the line between campaign finance and personal spending have failed. "It's going to be difficult," says Catherine Christian, a former New York financial prosecutor. https://www.bbc.com/mundo/noticias-internacional-65132772

With a design update, an extensively modernized premium ambience and clear advances in the areas of digitization, control, operation and equipment, the new edition of the BMW 3 Series is set to write another chapter in the worldwide success story of this model range. . The BMW 3 Series Sedan is presented in Ecuador to expand the offer of Premium vehicles of the brand in the country. This high-performance model features design updates to the front and rear that shed an even brighter light than ever on the sporty capability for which the BMW 3 Series Sedan is famous. With its elegantly sporty design and agile handling, the BMW 3 Series has provided a benchmark for driving pleasure in the premium midsize segment since day one. BMW headlights and grille in new design With its clearly structured surface, dynamic lines and large air intakes, the front apron adds even more emphasis to the sporty appearance of the new BMW 3 Series. The redesigned headlights and the double kidney grille also give the vehicle a strong presence. visual. The standard LED headlamps are now much slimmer, with clear contours and daytime running lights arranged in an inverted L shape to create a modern and harmonious look. Adaptive LED headlights are available as an option and are identified by blue accents inside their covers. Blue light effects under the headlamp units also give the front a striking, high-class appearance in the dark hours. The range of functions for the adaptive LED headlamps includes cornering light and non-glare matrix high beam, as well as dynamic headlamp range control and variable light distribution. Slightly modified contours and new double bars give BMW's double kidney grille an even more powerful look. High-gloss black air intakes located under the grille cool the brake system and add a sophisticated touch. New rear apron with a clean and modern surface design A higher proportion of surfaces painted in body color and a clean design give the rear apron of the new BMW 3 Series a particularly sophisticated appearance. Horizontal lines, slim light units and flared rear wheel arches accentuate the rear's width and muscular stance. The exhaust system tailpipes now measure 90 or 100 millimeters in diameter, depending on the engine variant. The focus on dynamism and modernity woven into the exterior design is also reflected in the restructured model range. The new BMW 3 Series already has a boldly sporty look in standard specification, a visual quality further emphasized by the now-standard M High-gloss Shadowline trim. In addition, the standard specification for the BMW 3 Series Sedan now includes 17-inch light-alloy wheels. Newly designed cockpit with BMW curved screen The interior of the new BMW 3 Series Sedan has received a comprehensive update. A new interpretation of the brand's trademark focus on the driver is embodied in the standard BMW curved screen. Here, a 12.3-inch information display behind the steering wheel and a control display with a 14.9-inch screen diagonal are merged into a single, high-resolution, fully digital unit. This state-of-the-art cockpit design has progressive digitization at its heart, allowing the number of buttons and controls to be significantly reduced in favor of touch and voice control. The selector lever for the eight-speed Steptronic transmission also has a new design. It is located on the control panel in the center console along with the Start/Stop button, the iDrive controller, the driving experience control buttons, the parking brake, and other vehicle functions. https://ekosnegocios.com/articulo/la-deportividad-y-el-lujo-llegan-a-ecuador-con-el-nuevo-bmw-serie-3-sedan-2023

On social networks, a campaign began to support a dog that had been adopted by the Presidency workers. Agents of the Animal Welfare Unit (UBA) arrived at the building located in the historic center of Quito. The dog was placed in a cage. From the municipal entity they reported that Santi, the pet, would have had an alleged aggressive behavior, so they could not take care of him on the spot. anti has a geriatric age, that is, he is considered an older adult. The dog was transferred to a Veterinary Care Center, Refuge and Temporary Reception (Cavrat) to carry out a clinical and ethological evaluation. Veterinarians will confirm the state of health and behavior of the animal. Several neighbors who became attached to Santi reported that they did not identify any aggressive behavior. In fact, they pointed out that he was very calm and docile with the people who passed through the place. A Twitter account was even created on social networks with his photos. In the publications it was denounced that the animal will be evicted from the building. Information was requested from the Presidency, however, they have not issued a statement in this regard. Preliminarily it was reported that the dog would have already found an adoptive home. From the UBA they indicated that their transfer to a home has not yet been confirmed. They called for citizen co-responsibility, so that he can enjoy his last years of life in a home that provides him with the necessary care. https://www.eluniverso.com/noticias/ecuador/santi-perro-presidencia-denuncia-edad-animal-bienestar-nota/

In the midst of strong clashes and protests, the French have decided to reject a proposal by their president Emmanuel Macron to increase the minimum retirement age, while the World Bank calls for the age to be increased worldwide to maintain the proportion of the po[CENSORED]tion economically active. Both facts reflect that the problem of social security extends around the world. Ecuador is no exception. According to Augusto De la Torre, former World Bank chief economist for the region, and current leader of the Inter-institutional Commission that seeks to create a reform for the pension system of the Ecuadorian Social Security Institute (IESS), there are great differences and similarities in the problems of pension systems around the world. Pay-as-you-go systems such as those in Ecuador, the US and France are facing the impact of higher life expectancy on the system deficit. These in turn transfer the problem to the tax issue. In this sense, various governments worldwide are trying to limit the fiscal impact. However, countries have different ways of absorbing the problem. In some that are advanced and have debt capacity, they do so by acquiring more debt to cover those gaps. However, for example, in France there would no longer be room for it and Macron proposes an increase in the minimum retirement age, which has generated this impressive reaction. In this sense, we can talk about the tragedy of the commons, and it is that since the resources belong to everyone, they also belong to nobody, people say that the treasury should take care of the problem, but we all end up affected by this problem, for example in the increase in taxes. Another interesting case is that of Argentina, for which the Government pays between 7% and 8% of GDP. There they are solving it by issuing banknotes, which ends up affecting inflation. Right now they are at 105% inflation and in danger of going into hyperinflation. In both cases this liquefies the pensions. Retirees receive the same pensions nominally, but the purchasing power is much lower. https://www.eluniverso.com/noticias/economia/problema-de-seguridad-social-no-es-exclusivo-de-ecuador-cuales-son-las-diferencias-con-francia-y-argentina-nota/

Among the main recommendations of experts is to constantly hydrate the skin and protect yourself from the sun. Skin care in cancer patients goes beyond a purely health issue of this organ, the largest in the human body. It also influences the psychological state of the patient: it determines how people perceive the cancer patient and how he perceives himself. Good skin care can greatly influence the patient's mood. Cancer treatments include radiation therapy and chemotherapy. The difference, explains the cosmetologist and dermocosmiatrist Gisela Salvador, is that radiotherapy sends high waves of radiation to eliminate tumors, while chemotherapy is a systemic treatment and is administered through a catheter. Radiotherapy also burns the area of the body where it is applied. Each patient, Salvador continues, has a skin reaction that depends on the "type of radiation and the type of chemotherapy" received. "A patient who is in stage 1, the initial stage of cancer, who is going to receive milder treatment, is not the same as a person with metastasis, who will receive a treatment that will cause much more damage to the skin," he explains. he. recommendations “The first thing is regarding hygiene. It is important that the patient does not use very alkaline soaps”, as they generate dryness. Instead of very strong soaps, Salvador recommends the use of syndet soaps, which are products without detergents or soaps with a neutral pH level. In the case of hands and nails, it is advisable to use moisturizing products and oils to strengthen the nails. In addition —he adds— the patient must try to hydrate by using creams with ceramides, which are essential lipids to keep the skin hydrated, and hyaluronic acid, important for retaining water in the tissues. Hot showers also dry out the skin, so patients should opt for short-term, lukewarm baths. https://www.eluniverso.com/larevista/salud/que-cuidados-de-piel-deberia-tener-un-paciente-con-cancer-nota/

Fears that the software will eliminate human jobs have recently multiplied around the world following the release of ChatGPT. The team of researchers conducted their analysis by linking 10 AI-powered applications, such as language, with 52 human skills, to understand if any are closely related. The results showed that telemarketers, teachers, school psychologists, and judges are among those most at risk from new technology. Fears that software will eliminate human jobs have recently been rampant around the world following the release of ChatGPT and its ability to perform eerily human professional tasks like writing emails and resumes. “The effect of AI at work will likely be multifaceted. In some cases, AI can replace work previously done by humans, and in other cases, AI can complement work done by humans,” the study read. One prominent example of how AI capabilities continue to advance is recent improvements in AI language modeling. In particular, ChatGPT, a language modeler released by Open AI in late 2022, has attracted a great deal of attention and controversy. The team used an AI occupational exposure measurement created by Edward Felten, also of Princeton University, in 2021. In that study, the 10 AI applications included: abstract strategy games video games in real time image recognition Visual answer to questions Imaging Reading comprehension Translation Speech recognition Instrumental Track Recognition While the 52 human skills, retrieved from the Occupational Information Network (O*NET) database used by the US Department of Labor to describe more than 800 occupations, included examples such as listening comprehension, oral expression, inductive reasoning and balance between arms and hands. https://www.eluniverso.com/larevista/tecnologia/a-nivel-mundial-maestros-y-jueces-estan-entre-las-20-ocupaciones-que-corren-riesgo-de-ser-reemplazadas-por-inteligencia-artificial-nota/

A research team from the University of Southampton plans to implement ultra-modern wing sails on merchant ships, with the aim of reducing carbon emissions. The group intends to create new software tools that accurately predict the performance of modern ships in the ocean when equipped with FastRig wing sails. These sails are developed by the British company Smart Green Shipping and have government financial support. Joseph Banks, lead scientist on the project, said global shipping needs to be decarbonised quickly. “Our team of researchers will investigate the complex interactions between the wing sails and the hydrodynamics of the ship, allowing for accurate predictions of the ship's performance that will be compared to the Pacific Grebe demo ship as part of the project,” explained Banks, a member of the Southampton Marine and Maritime Institute and who works at the forefront of the Winds of change project. As part of the two-year development programme, scientists will test the impact of an adapted 20-metre tall FastRig retractable wing sail on the commercial vessel Pacific Grebe, a 105-metre British ship. Banks considered this project innovative, because the sails can be retrofitted to existing boats to rapidly reduce emissions from existing boats. In addition, quieter and emission-free ships will be created in the future, which do not harm ocean environments and improve air quality in ports, towns and cities. https://www.eluniverso.com/larevista/tecnologia/investigadores-probaran-velas-en-grandes-buques-mercantes-para-reducir-la-contaminacion-nota/

Nick Movie: CITADEL - Tráiler Oficial | Prime Video España Time: 2023 Netflix / Amazon / HBO?: Amazon Duration of the movie: 28/04/2023 Trailer: 2:06

Live Performance Title: La Subasta (En Vivo) - Luis Alfonso Signer Name: Luis Alfonso Live Performance Location: Mexico Official YouTube Link: Your Opinion About the Track (Music Video): 9

Music Title: Amigos o Enemigos Signer: Noriel Release Date: 14/04-2015 Official Youtube Link: Informations About The Signer: - Your Opinion About The Track (Music Video): 8.5

Nick Movie: Transatlantic Time: 2023 Netflix / Amazon / HBO?: Netflix Duration of the movie: premiere 07/04/2023 Trailer:

Before following these steps, we recommend making a backup of your Mac. From the Apple menu  in the corner of the screen, choose System Settings or System Preferences. If you choose System Settings, click General on the left side of the window. Then click Software Update on the right. If you select System Preferences, click Software Update in the window. The Software Update option checks for new software. If Software Update finds new software, click the button to install it. The button might be called Update Now, Install Now, or Restart Now, for example. You may then be prompted to enter your administrator password. If Software Update says your Mac is up to date, that means there's no new software version currently available for your Mac model. Software Update only shows software that's compatible with your Mac. If you don't see Software Update If you don't see an item called Software Update, select View > Software Update from the System Settings or System Preferences menu bar. Or use Search in the corner of the window to search for Software Update. If your old Mac doesn't include Software Update, open the App Store. It's in the Applications folder. Then click the Updates from App Store tab to check for updates. You can also search for a software version by name. https://support.apple.com/es-lamr/HT201541

Welcome friends of Vandal Ware to a new PC Modding on Fridays in which we show you incredible equipment created to play that are also authentic works of art on an aesthetic level. This time we want to share with you the work of Mark's Fabrication that at the end of 2022 created an incredible team to celebrate the premiere of Portal with RTX by NVIDIA, giving life to an Aperture Science Portal Portable Device, that is, the tool we use to create portals in the game, turning it into a gaming PC packed with amazing details like the liquid cooling pump: As for the components, as you can imagine they are the latest model and the equipment has: NVIDIA GeForce RTX 4080 Founders Edition graphics card Intel Core i7-13900K processor RAM: Corsair VENGEANCE RGB DDR5 32GB (2 x 16GB) 5600MHz SSD: Corsair MP600 PRO 1TB Motherboard: ASRock Z790 PG-ITX/TB4 Power supply: FSP Hydro PTH X PRO ATX3.0 PCIe5.0 1000W https://vandal.elespanol.com/noticia/w5984/el-pc-modding-de-los-viernes-portal

SAO CAETANO DO SUL. - If there is a segment that has been growing significantly year after year, it is that of electric vehicles, which closed 2022 with almost 10% of world sales of passenger vehicles, against 8.3% the previous year, according to the consultancy EV Volume. But despite the rapid po[CENSORED]rization of future technology, many people still have doubts about how to drive a vehicle like this, the only one with zero emissions. "In fact, an electric car is even easier to drive than a conventional automatic vehicle," says Luiz Eduardo Martins, director of vehicle engineering for GM South America. Since EVs have a system called One Pedal, it is enough for the driver to relieve the pressure on the accelerator pedal for the vehicle to begin gradual braking, also taking advantage of the energy dissipated in the maneuver to potentiate the autonomy of the batteries. "A button on the dashboard activates this driving mode, and if there is a need for more abrupt braking, the driver must use the conventional brake pedal," explains Martins. Another advantage of electric vehicles is the absence of noise and vibrations from the engine, which makes long trips much more comfortable and pleasant, especially. EVs are also relatively very useful in terms of performance, with powerful starts that make them a lot of fun to drive. This is due to the fact that full engine power is instantly available and there is only one forward gear, which also helps maneuvering back into gear, giving a greater sense of safety when overtaking. https://media.gm.com/media/ec/es/chevrolet/news.detail.html/content/Pages/news/ec/es/2023/mar/0321-electrico.html

On a rainy and stormy day about 77 million years ago in what is now southeastern Alberta, Canada, a certain dinosaur was having a hard time. The adult Centrosaurus apertus, a medium-sized herbivorous cousin to the larger Triceratops that lived alongside Tyrannosaurus, had advanced malignant bone cancer on its shinbone. The cancer had possibly spread to other parts of his body and is almost certainly believed to be terminal. But this Centrosaurus probably didn't die of bone cancer, because before this could happen, it and the thousands of other Centrosaurus in its herd were struck down by a catastrophic flood, possibly caused by a tropical storm. Millions of years later, the bone bed preserved after this mass die-off event helped provide important evidence that these dinosaurs moved in huge herds. But the diagnosis of this particular dinosaur's osteosarcoma — a rare malignant bone cancer most commonly found in children and diagnosed in about 25,000 people a year worldwide — only came in 2020. It was the first time a malignant cancer had been diagnosed in a dinosaur and required a multidisciplinary team to confirm the case. "It turns out that the diseases that affected dinosaurs have essentially the same appearance as those that affect humans or other creatures," says Bruce Rothschild, a research associate in vertebrate paleontology at the Carnegie Museum of Natural History in Pennsylvania, United States. The results of this and other research are revealing previously unknown details of how dinosaurs lived and died. Some argue that they could also provide new insights into diseases that still plague us today. It was the first time a malignant cancer had been diagnosed in a dinosaur and required a multidisciplinary team to confirm the case. "It turns out that the diseases that affected dinosaurs have essentially the same appearance as those that affect humans or other creatures," says Bruce Rothschild, a research associate in vertebrate paleontology at the Carnegie Museum of Natural History in Pennsylvania, United States. The results of this and other research are revealing previously unknown details of how dinosaurs lived and died. Some argue that they could also provide new insights into diseases that still plague us today. https://www.bbc.com/mundo/topics/c7zp57yyz25t

5 signs of psychological abuse (and how you can help someone who is suffering from it) Psychological abuse is the regular and deliberate use of words or non-physical actions done to mentally and emotionally weaken, hurt, mani[CENSORED]te or frighten a person. It's like laser surgery: you can't see it, but its effects, in this case harmful, are there. It is about psychological or emotional abuse. It involves the regular and deliberate use of words or non-physical actions done to mentally and emotionally weaken, hurt, mani[CENSORED]te or frighten a person, as defined by SaveLives, a UK-based organization dedicated to fighting this type of abuse. The consequences of psychological abuse are as serious as those of physical abuse and can cause a series of health problems, such as depression and anxiety, physical problems such as stomach ulcers, heart palpitations and eating disorders, and insomnia, according to the National Health list. Service (NHS, the National Health Service of the United Kingdom). It may be that the aggressor does not value the achievements of the partner, makes humiliating comments or jokes, invalidates their emotions or blames them for situations for which they are not responsible. It has many faces and forms. Due to these characteristics it is difficult, both for the person who suffers it and for those around it, to detect if there is psychological abuse. The psychologists consulted warn that the signs must be observed in their entirety and that this is not a specific behavior, but a set of things that occur little by little, lengthened and sustained over time. https://www.bbc.com/mundo/noticias-64967795

"The future does not belong to the globalists. The future belongs to the patriots, " Donald Trump declared before the UN General Assembly in 2019, while, on the other side of the Atlantic, British Prime Minister Boris Johnson promoted his Brexit. And the governments changed, but the discourse not so much. "Our manufacturing future, our economic future, our solutions to the climate crisis, everything will be done in the United States," Joe Biden said at the White House as he announced his "Made in America" commitments in 2022. Has globalization been sentenced to death? "Hangs the sword of Damocles, the danger of a new fragmentation of the world, of deglobalization and decoupling," German Chancellor Olaf Scholzle told the 2023 World Economic Forum, expressing concern that the world is falling apart in politics. and financially. Globalization is the process by which people and goods move easily across borders, according to the World Economic Forum. Primarily, it is an economic concept: the integration of markets, trade, and investment with few barriers to slow the flow of goods and services between nations. "The tidal wave of globalization that we have experienced began around 1990, with the end of the Cold War and the opening of China, the integration of Europe, global agreements to reduce trade barriers and the development of the internet," explained Ian Goldin, professor of globalization and development at Oxford University, on the BBC's Analisys programme. For Goldin, "while globalization is far from perfect, it needs to be improved, not destroyed." "People forget that globalization has lifted more than a billion people out of poverty, not just in China but in other parts of the world," said Ngozi Okonjo-Iweala, director-general of the World Trade Organization (WTO). https://www.bbc.com/mundo/noticias-64945852

Although Beijing presented a peace plan last month that could have raised doubts about a distance from Moscow, Xi Jinping's visit to Russia at the invitation of Vladimir Putin definitively turns the page on a year of ambiguous neutrality since the start of the war in Ukraine . This is the Chinese president's ninth visit to Moscow, and the strategic partnership whose framework was established during the 2001 Sino-Russian friendship treaty will be central to the economic, energy and geopolitical changes of 2023. Xi and Putin expressed this certainty during their Farewell: Ongoing transformations, "unprecedented for more than 100 years, will be jointly led by China and Russia" Now exposed in public, the nature of the Sino-Russian partnership is also being heavily criticized by Washington: starting with the revelation that $12 million worth of Chinese drones have been sent to Russia since the start of the invasion and The White House's criticism of Xi's visit "suggests that China does not feel compelled to hold the president [who now has an international arrest warrant] to account for the atrocities committed in Ukraine." On Monday, ahead of his state visit to Russia, the Russian newspaper the Russian Gazette and the Kremlin-linked RIA Novosti news agency published an article by Xi titled "Moving forward to open a new chapter of friendship, cooperation and joint development between China and Russia. In the latter, the Chinese president reaffirms China's "objective and impartial position" in the war in Ukraine, while praising the "enduring friendship" with his Russian partner, whom he considers above all his "greatest neighbor and full member of the [legitimate] law of international organizations.” In more general terms, Beijing and Moscow exhibit the ambition of "a new vision, a new plan and new measures for the development of the Sino-Russian strategic partnership for global coordination", whose cement would be "civilizational values" that would resonate in the countries not aligned. Echoing many of the mantras of Xi Jinping's agenda, this "response to world changes" would above all be a response to the existential conflict with the United States, which would imply a new world order shared with Russia and the countries of the South. https://legrandcontinent.eu/es/2023/03/22/las-palabras-de-xi-en-moscu/

Ecuador is famous for the Galapagos Islands and the unique species that inhabit it. However, in the midst of such diversity, we have compiled 10 curious facts about Ecuador that will awaken your interest in this beautiful country. Read on to find out if Chimborazo is really the closest point on earth to the stars; Or if the Amazon jungle was named after the warrior women of Greek mythology. Although Ecuador is a relatively small country, there is something here for almost everyone. Therefore, this is our list of the 10 most fascinating curious facts about Ecuador: Ecuador owes its name to the equator line It might not surprise you to find out that the country is so named because the equator runs through it. In fact, Ecuador is the only country in the world named after a geographic feature. The official name of the country is "Republic of Ecuador". But maybe you didn't know that just outside Quito there is a famous monument to mark the equator line. The monument is about 240 meters from the actual equator, but still a good visit. There is a museum and some market style shops and restaurants to wander around. It is also possible to climb the half of the world monument and enjoy the landscape from above. Along the way there is an interactive museum to mark the "real" equator. Although the equator line is actually 5 kilometers wide and both museums are on it, only one of them is right in the middle. Yasuní Park is one of the most biodiverse places on the planet This National Park and biosphere reserve is located in the heart of the Ecuadorian Amazon. It is one of the most biodiverse places on the planet, home to species that are completely unique on Earth. Ecuador has more species of trees, amphibians, and bats in just 100 km than anywhere else in the world. There are hundreds of species of trees, reptiles and small animals such as the Titi or Yaguarundi Monkeys and small lions found only in America. In addition, there are much larger animals, such as the Green Anaconda and big cats, such as the jaguar. In fact, Ecuador has the largest snake in the world. There is also a large amount of crude oil in the park. This remains untapped due to a promise made in 2007 by the President at the time, Rafael Correa. The promise was to protect the park and its resources. https://www.ecuadorhop.com/es/datos-curiosos-de-ecuador/