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Doctors treating Russian opposition figure Alexei Navalny say he is out of an induced coma and his condition, since being poisoned, has improved.
He is responding to verbal stimuli, they said. Mr Navalny, 44, was flown to Germany after falling ill on a flight in Siberia in August.
His team allege he was poisoned on the orders of Russian President Vladimir Putin, who denies any involvement.
German doctors say the Putin critic was poisoned with a Novichok nerve agent.
On Monday, the Charité hospital in Berlin said in a statement that Mr Navalny was being weaned off mechanical ventilation.
"He is responding to verbal stimuli. It remains too early to gauge the potential long-term effects of his severe poisoning," it said.
It also said doctors were in close contact with Mr Navalny's wife.
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Mr Navalny's spokeswoman, Kira Yarmysh, tweeted: "News about Alexei. Today he was taken out of induced coma. Gradually he will be switched off from a ventilator. He responds to speech and to being addressed to."
Mr Navalny is an anti-corruption campaigner who in recent years has become the most prominent opposition politician in Putin's Russia.
What happened to Alexei Navalny?
Mr Navalny fell ill on 20 August on a flight from Tomsk to Moscow. His supporters suspect poison was placed in a cup of tea at Tomsk airport.
"Alexei started moaning and screaming. He was clearly in pain. He was lying on the floor in the part of the plane reserved for cabin crew," a passenger seated near Mr Navalny on the plane told BBC Russian.
The plane was diverted to Omsk, where the opposition politician was admitted to an emergency hospital. Russian officials initially refused to allow Mr Navalny to be transferred abroad for medical treatment but after three days he was flown by air ambulance to Berlin.

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