HeWhoRemains™

The sequel to Sony's animated film will arrive in June, but before that we can open our mouths with Zotac RTX 4070 graphics with a spidery appearance. Our friendly neighbor Spider-Man is going to have a very busy 2023 with a video game that is expected to arrive at the end of the year for PS5 and also with a new animated film, Spider-Man: Crossing the Multiverse. This Sony movie will be released in June and to gain strength ZOTAC Gaming and Sony Pictures have joined forces to launch a special edition of various models of graphics cards that will have a special Spidey design, this time designed to be mass-produced and not like the mod we saw yesterday. As of May 26, ZOTAC Gaming will put on sale three variants of Spider-Man's RTX 4070 graphics: Crossing the multiverse, finding us within this action the ZOTAC GAMING GeForce RTX 4070 AMP AIRO, ZOTAC GAMING GeForce RTX 4070 Twin Edge OC and ZOTAC GAMING GeForce RTX 4070 Ti AMP AIRO. In addition, all those who buy these graphics will have the chance to participate in a draw to win all kinds of gifts such as figures, stickers, t-shirts and even other graphics cards. What's new about Spider-Man 2 This Zotac and Sony promo comes on the same day that the actor who played Peter Parker in Marvel's Spider-Man 2 has announced that he has finished the motion capture process for the game that will be released on PlayStation 5 in the coming months. autumn. https://vandal.elespanol.com/noticia/w5995/zotac-gaming-lanza-una-gama-de-graficas-de-spiderman-cruzando-el-multiverso

Nickname: @Phoenix™ Video author: DarkPlayer GamingTV Name of the game: Burning Shores de Horizon 2 Link video: Rate this video 1-10:10/10

It also includes a headphone stand ready so that we have more order in our corner to play. The well-known brand of peripherals for gamers Turtle Beach continues to expand its catalog with other devices beyond its po[CENSORED]r headphones for gamers. On this occasion, there are two products that this American brand has announced, starting with a Fuel Dual Controller charging station for Xbox that is designed to be able to simultaneously connect two Xbox Series X/S controllers and be able to charge both. Batteries included with an autonomy of more than 22 hours per pack. In addition, this station includes a support for headphones specially designed for the "headsets" that the brand has designed for Xbox, although it can also be used with other models available on the market to keep everything tidier. "Earlier this week we entered a new category of products with the announcement of our Fuel VR charger and we're already adding another product to the Fuel family with our officially licensed Xbox Fuel Dual Controller Charging Station," said Juergen Stark, president and CEO of Turtle Beach Corporation. "With gamers flocking to the latest Call of Duty and other upcoming holiday game releases, it's as important as ever that gamers keep their gear charged and ready to go. The Fuel Dual Charger powers up Xbox gamer controllers and helps keep your gaming area clean by becoming the home for two Xbox Wireless Controllers plus a headset when not in use." https://vandal.elespanol.com/noticia/w5853/turtle-beach-anuncia-una-base-de-carga-doble-para-mandos-de-consolas-xbox-series-xs

Electronic Arts ends the mobile version of the battle royale for not reaching the expected 'quality bar'. Battlefield Mobile has been canceled to 'fulfill the vision' of the saga. Electronic Arts has announced that it will stop supporting Apex Legends Mobile, the iOS and Android mobile phone version of Apex Legends that was released in mid-May last year, while also canceling Battlefield Mobile, which received its first open beta in November last year, before its official release. On the other hand, the company will also close Industrial Toys, the studio behind the development of pocket Battlefield, which was founded by Alex Seropian, former Bungie CEO, and acquired by EA in 2018. The Apex Legends Mobile servers will no longer be available as of May 1 of this year. "At Respawn, our goal is to offer players games that are consistent. After a strong start, the content pipeline for Apex Legends Mobile has begun to fall short of that bar of quality, quantity, and cadence. For this reason, after months of Working with our development partner, we have made a mutual decision to end our mobile game," we can read in the statement. "Although disappointing, we are proud of the game we released, we appreciate the support of the Apex Legends community, and we are confident that this is the right decision for players," he adds. Despite this situation, Andrew Wilson, CEO of EA, revealed in a presentation of the company's financial results that the company has learned a lot from its experience with the game and that it "plans to reimagine an Apex Legends Mobile experience in the future". Additionally, it has been reported that virtual currency balances from the title can be spent on in-game content until its closure, while real money purchases will not be refunded. Why has Battlefield Mobile been cancelled? Regarding Battlefield Mobile, EA has stated in a brief part of the statement that "as the industry has evolved and our strategy to create a deeply connected Battlefield ecosystem has taken shape, we have decided to pivot from the current direction to meet better with our vision for the franchise and meeting the expectations of our players." https://vandal.elespanol.com/noticia/1350759665/ea-dejara-de-dar-soporte-a-apex-legends-mobile-y-cancela-battlefield-mobile/

It's Friday and that means it's the day we choose to share with you Friday's PC Modding, a section in which we show you the works of the most talented modders in the fish tank community who turn computers into true works of art. Today we want to show you the latest computer from mayhem-modz, a regular in this section who wanted to create a PC tribute to Halo, one of the most important shooter sagas in history linked to both the world of PC and Xbox: As for the components we find: Intel Core i7-11700K processor Inno3D Ichill RTX 3070 graphics card Motherboard: Asrock Stell Legends B560 RAM memory: Viper Patriot (32 GB) Storage: 2x Patriot Burst SSD 1.92 TB + 1x VPN110 PCI-e SSD 1 TB Power supply: Sharkoon Silent Storm 850 W Base chassis: Sharkoon REV300. https://vandal.elespanol.com/noticia/w5992/el-pc-modding-de-los-viernes-halo-parte-2

Sudan, a sprawling country in eastern Africa, experienced a turbulent weekend that left more than 180 dead and at least 1,100 injured. According to different international organizations, the deaths occurred as a result of clashes between members of the army and the paramilitary militias known as the Rapid Support Forces (RSF, for its acronym in English). So far most of the attacks between the two sides have taken place in the country's capital, Khartoum. But this confrontation on the ground is the result of a long chain of events, tensions, crises and political struggles that have not allowed the country to stabilize since the fall of the Omar al Bashir regime in April 2019. Among the reasons for the resurgence of violence is the lack of dialogue between the two main military leaders who remained in charge of the country to lead the nation towards a civil democracy: Mohamed Hamdan Dagalo, head of the RSF and better known as Hemedti, and Abdel Fattah. al Burhan, head of the army and president of the country. But among all the factors that contribute to the internal tension in Sudan, there is a key element: the African country has one of the largest gold reserves on the continent. Only in 2022, and according to the government, Sudan achieved exports close to US$2.5 billion, corresponding to the sale of 41.8 tons of gold. Most of the country's most profitable mines are controlled by Hemedti and RSF militias, which finance their operations by selling the precious metal not only to the Khartoum government but also to other buyers in neighboring countries. "Gold mines have become the main source of income for a country with many economic difficulties. And in these moments of tension they become a strategic objective," Shewit Woldemichael, an expert on Sudan's Crisis issues, explains to BBC Mundo Group. "And above all it has been one of the sources of funding for the RSF and one that the army views with some suspicion," she adds. At the same time, rampant extraction has caused a series of devastating effects in the areas around the mines, with a very high toll of people not only killed by the collapse of the mines, but also sickened by the mercury and arsenic that is used. in the extraction of this metal. But how did gold become this strategic element in the violence that Sudan is experiencing these days? Sudan and its "golden curse" Following the independence of the territories now known as Sudan from British rule, in 1956, a difficult reorganization process began, full of ups and downs. Along this path, the country found the main form of financing in oil production. However, towards the mid-1980s, an independence process began in the south of the country, which concluded in 2011, after fierce conflict and political decision-making, with the creation of the Republic of South Sudan. With that independence, Sudan lost two thirds of the money that came from crude oil exports. The decrease in resources intensified internal tensions between various ethnic groups, militias, and armed groups that coexist in the country. In 2012, it was revealed that an area called Jebel Amir, in the north of the country, could contain enough gold reserves to alleviate the difficult economic situation in the country. "This was clearly seen as a godsend, considering what they had lost with South Sudan," Tufts University Sudan analyst Alex de Waal told the BBC. "But it soon became a curse because what it did was intensify the fight for control of the territory between various sides and gave rise to an uncontrolled gold rush," he adds. According to local records and De Waal himself, tens of thousands of young people flocked to that region of the country to try their luck in shallow mines with rudimentary equipment. Some struck gold and became rich, others were crushed in collapsing pits or sickened by mercury and arsenic poisoning used to process the nuggets of the metal. In 2021, 31 people died after a disused gold mine collapsed in West Kordofan province. And without going any further, on March 31, another 14 people died when another mine collapsed in the north of the country. According to the Sudan University of Science and Technology, in analyzes carried out in watersheds near mining areas in 2020, mercury concentration levels of 2004 parts per million (ppm) and arsenic of 14.23 ppm were found. According to the WHO, the permitted levels are 1 ppm for mercury and 10 ppm for arsenic in water. "The use of cyanide and mercury will definitely lead to an environmental disaster in the country," El Jeili Hamouda Saleh, a professor of environmental law at Bahri University in Khartoum, told local radio. "In the country there are more than 40,000 gold mining sites. Some 60 gold processing companies operate in 13 states of the country, 15 of them in South Kordofan. This is not going to end well, because they do not comply with environmental requirements. ", he pointed out. But it was not the only thing that happened. A tribal leader known as Musa Halil and loyal to Al Bashir took control of the territory after an ethnic cleansing that claimed the lives of more than 800 people residing in the area. Halil began mining for the gold and selling it, not only to the government in Khartoum but also to other buyers. However, in 2017 -after Halil, accused of crimes against humanity, was handed over to the international authorities- Hemedti, leader of the RSF and who had armed himself to defend Al Bashir from any military threat, took control of the exploitation. mining. At that time, income from the sale of gold represented about 40% of the country's exports. Literally a gold mine. "That gold made Hemedti the country's leading metal trader and with it, he also gained control of the border with Chad and Libya," De Waal says. A path to democracy The truth is that, after the fall of Omar al Bashir in 2019 due to a coup carried out by the military, the country was left in the hands of the two men who controlled the armed groups: Hemedti and Al Burhan. "Thanks, among other factors, to the control of gold production, with 70,000 men and more than 10,000 armed pickup trucks, the RSF became the de facto infantry of Sudan, the only force capable of controlling the streets of the capital, Khartoum. , and other cities," says De Waal. In 2021, both leaders promised -in a timid alliance- to start a process that would end in a civil and democratic government for Sudan. "In that alliance, ratified last December, it was clear that the gold production was going to be handed over to the civilian government that was elected. But evidently, the growing power of Hemedti made people around Al Burhan ask to control the actions of the RSF," explains Woldemichael Although he clarifies that there are many forces that also want to participate in the control of gold in northern Sudan "For that reason, the Al Burham-controlled army tried to use the security sector reform negotiations [as part of broader political transition negotiations] to control the RSF, under conditions that Hemedti was not going to accept." , indicated. That was one of the many factors that has escalated the tension to the violent clashes over the weekend. Although other factors still need to be added that may end up destabilizing the country. "As the fighting in Libya subsides, it is expected that many more Darfur fighters who had been fighting in Libya will end up returning, furthering the fight over resources, including gold mines," he noted. For analysts, the truth is that peace will depend above all on the effects of international condemnation of the use of violence in the country. "It is not certain that either side will win outright, so as the casualties on both sides unfortunately increase and therefore internal and international condemnation increases, I think they will decide to negotiate," he concluded. https://www.bbc.com/mundo/noticias-internacional-65297706

If you've ever cared for a tricolor cat, it's almost certainly a female. Males with three coat colors are very rare: it is estimated that only one in 3,000 tricolor cats is male – although other estimates put this figure at one in a thousand, since it is difficult to verify statistically – , simply because genetics do not allow it. This is the curious reason why the vast majority of tricolor cats are female. THE COLOR IS IN THE GENES The coat of cats can present three basic colors: black, white and orange. The other colors, such as gray or brown, are actually a combination of these. And it is that the color is encoded in two different chromosomes: these contain the genes responsible for pigmentation and the colors that the fur will have depend on their combination. One of these, the gene responsible for producing the white pigment, is encoded on a chromosome possessed by all cats, regardless of sex. Instead, the black and orange pigments are produced by a gene that is only present on the X sex chromosome; and the color that is displayed depends on the allele that a particular individual possesses. Alleles are “alternative” forms of the same gene that produce genetic variations, such as hair color, eye color, or blood group. When a cat, or any other living being, inherits a gene that has several forms, only one of them is expressed. In the case at hand, each allele of said gene activates a different pigment (eumelanin for black and pheomelanin for orange). In females, who have two X chromosomes, there is the possibility that the gene present in each of them manifests itself in the form of different alleles and therefore generates black and orange pigmentation at the same time; Of course, it can also be the case that the genes on both X chromosomes manifest as the same allele and therefore only have one of these pigments. On the other hand, each of the three colors can be manifested or not and, as a consequence, the cats can be one, two or three colors. These can also be combined: for example, a cat that manifests the colors black and white can have gray fur, totally or partially. CAN THE MALES BE TRICOLORED? The case of males is different, since instead of having two XX chromosomes they have one X and one Y. Therefore, there is only one allele responsible for the black or orange color, which can manifest as either of the two and that , as in females, can be combined or not with the gene responsible for the white color and give rise to various possibilities, but always limited to a maximum of two base colours. Or so it should be. The reality is that male tricolor cats do exist, but they are the result of a genetic alteration called Klinefelter syndrome. This mutation only affects males and consists of a duplication of the X chromosome, resulting in an XXY combination or, in rarer cases, even more X chromosomes. As a result, like females, if multiple alleles are manifested in the form of different colors, the male cat may have both black and orange fur; and if the white pigment is also manifested, it will be tricolor. This possibility is very rare: it is difficult to give an exact number, but it is estimated that only one male cat in 1,000 or 3,000 has a tricolor coat, and that even fewer - approximately one in 10,000 - are fertile, since the most common consequence of Klinefelter syndrome is infertility. The reason for this mutation is usually inbreeding, which is why it is more frequent in isolated po[CENSORED]tions and in cats from selective breeding. On the other hand, this characteristic is not hereditary, so if it happens that a tricolor male has offspring, these will not have a higher probability of also being tricolor males. https://www.nationalgeographic.com.es/mundo-animal/casi-todos-los-gatos-tricolor-son-hembras-y-este-es-el-motivo_19352

MG has revealed a new electric roadster called the Cyberster that will hit the streets of Europe in the summer of 2024. The Cyberster's curvy design is fairly similar to that of the eponymous 2021 concept car, even keeping the wild scissor doors. Leaked Chinese government documents revealed that the Cyberster is a bit larger than a BMW Z4, and will have a top speed of 124 mph. The octagonal MG badge used to be synonymous with small, grin-inducing roadsters, from the T-Type of the '30s and '40s to the MGB of the '60s and '70s and even into the '90s with the MG F. Now the brand—under the control of Chinese state-owned automaker SAIC since 2007—is looking to return to its roots with the new Cyberster, an electric roadster that goes on sale in Europe next summer. First previewed by a concept in 2021, the production Cyberster revealed this week at the Shanghai auto show hews closely to the concept's design, albeit with toned-down proportions. The bodywork is sleek, with a sharply sloped front end and crisp creases that run into squared-off taillights with arrow-shaped LED elements pointing outwards. The power-folding soft-top covers a stylish interior swathed in red leather, and the production roadster retains the fantastical scissor doors from the concept. MG hasn't officially shared detailed specifications on the Cyberster, but some information was uncovered in a filing with China's Ministry of Industry and Information Technology last week. The document listed the Cyberster as measuring 178.5 inches long, 75.3 inches wide, and 52.3 inches tall, which is about 8.0 inches longer than a BMW Z4, nearly 2.0 inches wider, and almost one inch taller. The electric powertrain, however, results in a hefty 4,376-pound curb weight, versus the 3,535 pounds for the gas-powered BMW. The Cyberster will feature two electric motors, with a peak output of 201 hp from the front motor and 335 hp from the rear unit. The document also listed the top speed at 124 mph. No other performance metrics were available, but we expect a pretty quick sprint to 60 mph given the Cyberster's power output. More details about the electric roadster will come before its launch in 2024, but unfortunately there is virtually zero chance that the Cyberster ever reaches American shores. https://www.caranddriver.com/news/a43634289/mg-honors-its-heritage-with-cyberster-electric-roadster-for-europe/

When in April 2003, after 13 years of effort to sequence the entire "book of life" that had been encoded within the human genome, the work was said to be "complete," expectations were high. The Human Genome Project, costing around $3 billion, was expected to produce treatments for chronic diseases and shed light on all that is genetically determined in our lives. But even as the press conferences were being held to announce the triumph of this new era of biological understanding, this instruction manual for human life had already delivered an unexpected surprise. At the time, the prevailing belief was that the vast majority of the human genome would consist of instructions for making proteins, the building blocks of all living organisms that perform a bewildering variety of functions within and between our cells. With more than 200 different types of cells in the human body, it made sense to think that each of them needed its own genes to carry out its functions. The emergence of unique protein assemblies was thought to have been vital in the evolution of our species and our cognitive powers. (After all, we are the only species capable of sequencing its own genome.) Instead, it turned out that less than 2% of the 3 billion letters in the human genome are devoted to proteins. Only about 20,000 distinct protein-coding genes were found to exist in the long lines of molecules known as base pairs that make up our DNA sequences. Geneticists were surprised to discover that humans have a similar number of protein-making genes as some of the simplest creatures on the planet. Suddenly, the scientific world was faced with an uncomfortable truth: Could much of our understanding of what makes us human actually be wrong? "I remember the incredible impact of this," says Samir Ounzain, a molecular biologist and CEO of a company called Haya Therapeutics, which is trying to use our understanding of human genetics to develop new treatments for cardiovascular disease, cancer and other chronic ailments. "That was the moment when people started to question that maybe we have a wrong conceptualization of biology," he said. The remaining 98% of our DNA became known as dark matter, or the dark genome, a mysterious hodgepodge of letters with no obvious meaning or purpose. Initially, some geneticists suggested that the dark genome was simply junk DNA, or the dumping ground of human evolution: the remnants of broken genes that had long ceased to be relevant. However, to others it was always obvious that the dark genome was crucial to our understanding of humanity. "Evolution has absolutely no tolerance for garbage," says Kári Stefánsson, CEO of the Icelandic company deCODE genetics, which has sequenced more complete genomes than any other institution in the world. "There must be an evolutionary reason for maintaining the size of the genome," he says. Now, two decades later, we have the first hints of the role of the dark genome. Its main function appears to be the regulation of the process of decoding, or expression, of protein-producing genes. It helps control how our genes behave in response to all the environmental pressures our bodies face throughout our lives, from diet to stress, pollution, exercise, and how much sleep we get—a field known as epigenetics. Ounzain says he likes to think of proteins as the hardware components of life, while the dark genome is the software that processes and responds to external information. As a result, the more we learn about the dark genome, the more we understand human complexity and how we became who we are. "If you think of us as a species, we are masters of adapting to the environment at all levels. And that adaptation is information processing," Ounzain explains. "When you come back to the question of what makes us different from a fly or a worm, we realize more and more that the answers lie in the dark genome." Transposons and our evolutionary past When scientists began examining the book of life in the mid-2000s, one of the biggest challenges was that non-protein-coding regions of the human genome appeared to be riddled with repetitive DNA sequences known as transposons and comprising nearly half the genome in all living mammals. "Even assembling the first human genome was made more problematic by the presence of these repetitive sequences," explains Jef Boeke, who directs the Dark Matter Project at Langone University in New York. At first, geneticists ignored transposons. Most genetic studies choose to focus exclusively on the exome, the small region of the genome that codes for proteins. But over the past decade, the rise of more sophisticated DNA sequencing technologies has allowed geneticists to study the obscure genome in greater detail than ever before. In one experiment, the researchers knocked out a specific transposon fragment in mice. This caused half of the animal's pups to die before birth and showed that some transposon sequences may be critical to our survival. Perhaps the best explanation for why transposons exist in our genomes might be that they are extremely old, dating back to the earliest forms of life, Boeke says. Other scientists have suggested that they come from viruses that invaded our DNA throughout human history before gradually being repurposed in the body to confer some useful purpose. "Most of the time, transposons are pathogens that infect us and can infect cells in the germ line, the type of cells that we pass on to the next generation," says Dirk Hockemeyer, an assistant professor of cell biology at the University of California, Berkeley. "Then they can be inherited and lead to stable integration into the genome." Boeke describes the dark genome acting as a living fossil record of crucial alterations in our DNA that occurred long ago in ancient history. One of the most fascinating things about transposons is that they can move from one part of the genome to another. This, in addition to giving them their name, creates or reverses mutations in the genes, sometimes with dramatic consequences. The movement of a transposon to a different gene may have been responsible for tail loss in the great ape family, leading our species to develop the ability to walk upright. "Here's this one thing that happened that had a huge effect on evolution, giving rise to a whole lineage of great apes, including us," Boeke says. But just as our growing understanding of the dark genome is explaining more about evolution, it may also shed new light on why diseases arise. Ounzain points out that if you look at genome-wide association studies (GWAS), which look for genetic variations among large numbers of people to identify those linked to diseases, the vast majority linked to chronic diseases such as Alzheimer's, diabetes and heart disease are not in the protein-coding regions, but in the dark genome. The dark genome and disease Panay, in the Philippines, is best known for its sparkling white sands and influx of tourists. But this idyllic setting hides a tragic secret. The island has the highest number of cases in the world of an incurable movement disorder called X-linked dystonia-parkinsonism (XDP). Like Parkinson's disease, people with XDP develop a variety of symptoms that affect their ability to walk or respond quickly to various situations. Since this disease was first discovered in the 1970s, it has only been found in people of Filipino descent, something that had long been a mystery until geneticists discovered that all of these individuals have the same unique variant of a gene called TAF1. The onset of symptoms appears to be driven by a transposon in the middle of the gene, which can regulate its function in a way that, over time, causes damage to the body. This genetic variant is believed to have first emerged around 2,000 years ago, before being passed on and establishing itself in the po[CENSORED]tion. "The TAF1 gene is an essential gene, necessary for the growth and multiplication of all types of cells. When you modify its expression, you get this very specific defect that manifests as this horrible form of parkinsonism," says Boeke. This is a simple example of how some DNA sequences in the dark genome can control the function of various genes, either turning on or repressing the process of turning genetic information into proteins in response to environmental cues. The dark genome also provides instructions for the formation of several types of molecules, known as non-coding RNAs, which can have various functions ranging from helping to assemble proteins, blocking the process of protein production, or helping to regulate gene activity. . "The RNAs produced by the dark genome act like orchestra conductors, directing how your DNA responds to the environment," says Ounzain. It is these non-coding RNAs that are now increasingly being seen as the link between the dark genome and various chronic diseases. The idea is that if we constantly give the dark genome the wrong signals, for example through a lifestyle of smoking, poor diet and inactivity, the RNA molecules it produces can send the body into a diseased state, altering the activity of genes in a way that increases inflammation in the body or promotes cell death. It is believed that certain non-coding RNAs can turn the activity of a gene called p53 on or off, which normally works to prevent tumor formation. In complex diseases such as schizophrenia or depression, a whole cacophony of non-coding RNAs may be acting in synch to decrease or increase the expression of certain genes. But our growing appreciation of the importance of the dark genome is already leading to new approaches to treating these diseases. While the drug development industry has generally focused on proteins, some are realizing that it may be more effective to try to disrupt the non-coding RNAs that control the genes in charge of these processes. In the field of cancer vaccines, companies sequence DNA from patients' tumor samples. Thus they seek to identify a suitable target for the immune system to attack. Most have focused only on the protein-coding regions of the genome. However, Germany's CureVac is pioneering an approach where they also look at non-protein regions in the hope of finding a point that can disrupt cancer at its source. Ounzain's company, Haya Therapeutics, is currently running a drug development program focused on a series of non-coding RNAs that drive the formation of scar tissue, or fibrosis, in the heart, a process that can lead to heart failure. One hope is that this will minimize the side effects that come with many common medications. "The problem with drug proteins is that there are only about 20,000 in the body and most of them are expressed in many different cells and pathways that are not related to disease," says Ounzain. "But the dark genome is exquisitely specific in its activity. There is a part of the non-coding RNA that regulates fibrosis exclusively in the heart, so by treating it, you have a potentially very safe medicine," he adds. the unknowns At the same time, emotions must be tempered. We barely scratch the surface in terms of understanding how the dark genome works. We know very little about what geneticists describe as the ground rules: how do these non-protein coding sequences talk to each other to regulate gene activity? How do these complex webs of interactions manifest over time in disease traits, such as the neurodegeneration seen in Alzheimer's? "We're just at the beginning," says Hockemeyer. "The next 15 to 20 years will be about identifying specific behaviors in cells that could lead to disease and then trying to identify the parts of the dark genome that might be involved in modifying these behaviors. But now we have tools we didn't have before to investigate this." One of those tools is gene editing. Boeke and her team are currently trying to learn more about how XDP symptoms develop by replicating the TAF1 gene transposon insertion in mice. In the future, a more ambitious version of this project could attempt to understand how non-protein-coding DNA sequences regulate genes by building synthetic DNA fragments from scratch and transplanting them into mouse cells. "Now we're involved in at least two projects where we take a large amount of DNA that doesn't do anything and then try to install all these elements on it," Boeke says. "We put a gene there, we put a noncoding sequence right in front of it, and another one far away, and we see how this gene behaves. Now we have the tools to build pieces of the dark genome from the bottom up and try to understand it," he says. Hockemeyer predicts that as we learn more, the genetic book of life will continue to throw up unexpected surprises, just as it did when the first genome was sequenced 20 years ago. "There are a lot of questions. Is our genome still evolving over time? Will we be able to fully decode it? We're still in this dark, open space that we're venturing into and there are great discoveries to be made." https://www.bbc.com/mundo/vert-fut-65311694

Russia has a plan to sabotage wind farms and communication cables in the North Sea, according to a new joint investigation by Danish, Norwegian, Swedish and Finnish public television networks. It ensures that Russia has a fleet of ships that appear to be fishing and oceanographic research vessels in the North Sea, which carry underwater surveillance equipment and are located in key locations for possible sabotage. The BBC has information that UK officials are aware of the Russian programme, which includes the presence of spy craft in British waters. The first in a series of reports on the matter will be broadcast on Wednesday by DR in Denmark, NRK in Norway, SVT in Sweden and Yle in Finland. Marine exploration as a facade A Danish counterintelligence officer assured that sabotage plans are being prepared in the event of a full and open conflict with the West. For his part, the Norwegian intelligence chief told the broadcasters that the program was considered very important to Russia and was being run directly from Moscow. The stations claimed to have had access to intercepted Russian communications and that they indicate that the so-called ghost ships sail in Nordic waters, but have turned off their transmitters so as not to reveal their location. The report focuses on a Russian ship called the Admiral Vladimirsky. She is officially an expeditionary oceanographic or underwater research vessel. However, in the investigation it is stated that she is, in fact, a spy ship. The documentary features an expert from the British Royal Navy who tracked the movements of the ship in the vicinity of seven wind farms off the coast of the United Kingdom and the Netherlands. The expert assured that the Russian vessel slows down when it approaches coastal areas where there are windmills and loiters in the area. Likewise, he said that she sailed for a month with the transmitter turned off. More reason to be suspicious As a reporter from the investigation team approached the Vladimirksy in a small boat, a masked individual carrying what appeared to be a military assault rifle emerged threateningly. The same ship was reportedly sighted off the Scottish coast last year. The vessel was seen entering the Moray Firth (an estuary in northern Scotland) on November 10. The vessel was about 30 nautical miles (55.6 kilometers) east of Lossiemouth, home to Britain's Royal Air Force fleet of maritime patrol aircraft, before slowly heading west. The BBC understands that the British authorities are aware of Russia's intention to carry out what is known as underwater mapping, including the use of ships moving in its territorial waters. "If there are specific threats against the United Kingdom, they will be investigated," said some sources, who refused to clarify what type of monitoring they are doing to this and other vessels. In February, Dutch intelligence issued a rare warning about activities that could indicate preparation for disruption or sabotage of marine infrastructure. The head of the country's military intelligence said a Russian ship had been detected near a wind farm in the North Sea and was mapping certain locations. "We have seen in recent months that Russian actors have been trying to figure out how the energy system works in the North Sea. This is the first time we have seen this," General Jan Swillens said. Preparing all the options Reconnaissance of sensitive sites is not unusual, and Western countries are likely to carry out similar activities against Russia. It is possible that these actions seek to prepare offensive plans in case the current conflict in Ukraine escalates. One option could be to damage communications or knock down countries' power systems to cause chaos. So far, the evidence that an imminent sabotage is being prepared is scant. The investigation raises the possibility that such vessels were linked to an incident last year south of Norway's Svalbard archipelago, when an underwater data cable was severed. Skripal on British soil. The cable served the world's largest commercial ground station for satellite communications. Norwegian police have said they believe "human activity" was behind the shooting, but have not formally charged anyone. On April 13 this year, Norway expelled 15 Russian officials, accusing them of espionage. It was the latest in a wave of expulsions across Europe after the invasion of Ukraine in February. In October, British police declared a major incident in the Shetland Islands, a UK archipelago near Norway, after an undersea cable failed. The incident severely hampered communications and "fishing boats" were blamed for it at the time. Wires are regularly cut by accident and so far the BBC understands that no premeditated hostile actions are believed to have taken place. However, in recent months there has been one clear and significant act of sabotage: the destruction of a section of the Nord Stream gas pipeline in September. The facility was designed to transport gas from Russia to Europe. At the time, many accused Russia, but other reports have since suggested other possibilities, including pro-Ukrainian actors. The investigations continue. Russian military intelligence (GRU) has been linked to both sabotage of infrastructure and poisoning of people. A GRU team was accused of attempting to assassinate former Russian spy Sergei Skripal in the English city of Salisbury in 2018 with Novichok nerve gas. Members of the group that tried to take down Skripal are also suspected of being behind the 2014 bombing of an arms cache in a Czech forest. https://www.bbc.com/mundo/noticias-internacional-65324645

Jabo H. Pizarroso reveals to us the censorship that was implemented for 40 years in the United States and that was based on the Hays Code, which had three principles of a very broad nature. The filmmakers used ingenuity and complicity to overcome censorship and tell what they really wanted Oh, the censored kisses and more! We return to the celebration of International Kissing Day to approach a moment in the History of Culture of the last twentieth century in which for almost forty years a censorship code was implemented in the United States that affected Hollywood films. And not only to Hollywood movies, but also to many cultural expressions, both cinematographic and musical or literary. Censorship that lasted until the end of the sixties. We cannot forget the censorship of the work of Henry Miller or Lolita, by Nabokov. What began in the cinema spread through many arts and we could say that it even reaches today. Jabo H. Pizarroso tells us how the film directors of the time fought against censorship, who used their ingenuity to the extreme to overcome it and establish double and triple meanings. And it is that, one thing was what was seen on the screen and another thing was what was below what we saw and heard. https://www.eitb.eus/es/radio/radio-vitoria/programas/radio-vitoria-gaur/detalle/9175787/la-censura-de-besos/

Live Performance Title: Myke Towers "EXTRA EXTRA" (En Vivo) | Open Mic Signer Name: Myke Towers Live Performance Location: - Official YouTube Link: Your Opinion About the Track (Music Video):10/10

Artist: Nio Garcia Real Name: Luis Antonio Quiñones García Birth Date /Place: 03/04/23 / San Juan, Puerto Rico Age: 34 Social status (Single / Married):- Artist Picture: HERE!! Musical Genres: Urbano Latino Awards: HERE!! Top 3 Songs (Names): Te Bote Remix, Mirame Remix, La Jeepeta Other Information: Luis Antonio Quiñones García, known by his stage name Nio García or Che Robotico, is a Puerto Rican singer, songwriter, and dancer.

Music Title: Gasolina (feat. Myke Towers) Signer: Daddy Yankee Ft Myke Towers Release Date: 18/04/23 Official Youtube Link: Informations About The Signer:- Your Opinion About The Track (Music Video):10/10

Nick: @Phoenix™ Real name: Luis Prieto How old are you?: 20 Which Games you play? and for how long?(each of them): I have played many games : Cs 1.6, Minecraft, GTA V, Battlefield 4, DeadPool, MK 9 Etc. Where are you from?(country and city): Venezuela - Maracaibo Describe yourself(at least 50 words): Is this necessary? Note some of your qualities: - Tell us some of your defects: Don't have Had you before any kind of responsabilities(describe it): If I have a son On which category/categories have you been active lately?(describe your activity): In VGR, Journalist, Devil Harmony and a bit of gfx Which category/project you want to care off?: Devil Harmony How well you speak english?(and other languages): 70% Good, only english Do you use TS3? Do you have an active microphone?: Yes/No For how long can you be active after you get accepted?(days, weeks, months, years): Maybe months, I don't know Contact methods: PM On Forum, TS3 or Discord : Ferxxo444#8552 Last request: Never

Can i joinx2?

Several users have reported to Microsoft this bug that affects one of the optional protections related to kernel isolation. Windows 11 has proven to be a very complete operating system to play with, although it has not been free of problems and failures (in reality, no system is) that have been solved through updates that also add new content or cover security holes. However, the latest system update comes with an error under the arm that our reader Javier García has informed us about and that several people are complaining about through the official Microsoft forums because it makes one of the functions work erratically. protections of Windows Defender, the antivirus that Windows itself incorporates. Specifically, this failure causes local authority protection (LSA) to be deactivated, one of the optional protections that are included within the kernel isolation security features and that, simply explained, helps us protect the credentials that we have stored in the operating system in a more secure way by preventing drivers and other items without a secure signature from being loaded into the system. This protection, initially, is deactivated by default in Windows 11 but those who wanted to maximize their security and have it activated have found that it has been automatically deactivated and, when trying to activate it, they have found an erratic operation like that of a user called Setacraft that after turning it on, he found that "the option was still on, but it was still asking me to reboot, so I rebooted again, and despite the reboot, it kept telling me to reboot to get it on, so I tried turning it off. the option, reboot, and turn on the option and reboot... and it keeps telling me to reboot even though the option is on." At the moment Microsoft has not ruled on this bug and at Vandal Ware we are going to contact them to see if they are preparing some kind of update to correct the bug or if they have any temporary solution beyond not updating Windows 11 if you want to have it activated (or to go back to the previous version in case you have already updated the operating system). In the future LSA will be activated by default Just this week we learned that Microsoft plans for Windows 11 to activate this LSA protection by default, something that they have already applied in the beta versions of the operating system and that they will implement in the "public" version in the future. Precisely, it may be that preparing the system for this change is generating this conflict. As for the problem, if you dedicate yourself to playing, Microsoft itself recommends deactivating the kernel isolation protections to gain performance (and reactivating them when you finish playing, which is very tedious) so it is something that in principle does not always affect us too much. and when we go carefully on the internet (something that on the other hand we should always do). https://vandal.elespanol.com/noticia/w5980/la-ultima-actualizacion-de-windows-11-viene-con-un-error-que-afecta-a-la-proteccion-lsa

We tested these Razer headphones designed for PS5 but compatible with all kinds of Bluetooth devices that have turned out to be comfortable, with great autonomy and very good sound. The world of headphones usually leaves us with all kinds of headsets to play and at Vandal Ware we have already analyzed all kinds of the most diverse models, usually focusing on the headband "headsets" that we usually wear in front of our PC. What we have not done so much is talk about wireless button options, headphones that are becoming more common, especially for their comfort of use with mobile devices, something that we are going to change today by talking about the Razer Hammerhead Hyperspeed, wireless headphones of this type especially designed for PlayStation consoles but which are also versatile with other devices and with which we have received a most pleasant surprise. Specifications Response frequency: 20 Hz – 20 kHz Impedance: 16 ohms Sensitivity: 91dB @ 1mW / 1kHz Headphone power input: 5 mW (maximum input) Driver: 10mm Connectivity: Hyperspeed Wireless and Bluetooth 5.2 Active noise cancellation Weight: 53g Autonomy: Up to 30 hours with the charge included in the case No-Drop Comfort As usual, we are going to tell you about the input experience at the level of comfort, repeating ourselves as always like a broken record, telling you that headphones that sound very good are useless if they are not uncomfortable or, in the case of this button model, if they are They don't fit well in the ear and fall out every so often. Luckily, these Razer headphones are very comfortable headphones that fit perfectly in the ear. As you can imagine, their weight is very light and as soon as we put them on we directly forgot that they are on thanks to their comfort, the absence of cables and they also adapt perfectly to the ears, staying well attached and not falling off at any time, even when we have used them together with a mobile device walking down the street from one place to another listening to music or our podcast. In addition, the headphones include three types of rubber bands that can be easily replaced and that adapt to all types of ears to precisely seek the greatest comfort and at the same time that they remain well attached and avoid the cumbersome thing it is to have to reposition or adjust this type of headphones every few minutes. Top sound for one earbuds The next point, as you can imagine, is the sound, counting here with a very good quality taking into account the type of headphones we are talking about, reacting very well to all types of frequencies and having very good audio behavior while we play. on all types of platforms, also highlighting the cleanliness or clarity of the dialogues in video games or other multimedia content. Along with this good sound we have to comment that we can also isolate ourselves from the outside thanks to its active noise cancellation system that works quite effectively and that we can configure thanks to the Razer Audio app in which we can choose to activate or deactivate this noise cancellation. noise or opt for a mode that lets in some ambient sound, reducing noise but leaving the sounds of human voices clear in case we have to have a conversation. Speaking of conversations, as you can imagine, Razer's headphones include microphones both for the use of noise cancellation and for talking with our fellow gamers. As usually happens in these cases, this microphone perfectly fulfills its function and offers a clear signal of our voice without frills. Total versatility and good autonomy One of the strongest points of the Razer Hammerhead Hyperspeed is its versatility. From the outset, this particular model is designed for PlayStation and that we can connect to PS5 or PS4 to use headphones with Hyperspeed Wireless technology that reduce latency to the minimum possible to be able to enjoy a good signal in games avoiding lip sync problems or of delay in the sound that we can find with other devices if they do not have a good quality of wireless signal retransmission. But in addition, this dongle can also be connected to other devices that have a USB port and in fact, these headphones are compatible with any device with a port of this type or with Bluetooth 5.2 connectivity that is also present. Without going any further, we have used them without problems on a PS5, on PC and on iOS and Android devices without having a single problem with them. In addition, the aforementioned Razer Audio app allows us to control various equalization parameters of these headphones and also control their RGB LED lighting. On the other hand, the autonomy of these headphones is about 5 or 6 hours (depending on whether we have the lighting or noise cancellation activated) and they include a case that recharges them to be able to use them for up to 30 hours, so we can use them a while, store them in the case and charge them until the next use. As for the charging time of the case, it is approximately one hour. Versatile headphones with good sound The truth is that we are quite satisfied with these Razer Hammerhead Hyperspeed (PlayStation) headphones both for their sound quality and for their comfort, performance and versatility, also having a price of €179.99 which seems quite well adjusted for everything these headphones offer us. https://vandal.elespanol.com/reportaje/ware-analisis-razer-hammerhead-hyperspeed-playstation-auriculares-de-boton-todoterreno

It has 15 programmable LCD buttons with a compact form factor so that streamers and content creators have easier control of their menus, sounds.. Razer, the brand of products and lifestyle for gamers, has been entering the increasingly attractive market of devices and accessories specially designed for content creators, an activity closely related to video games in which they are increasingly interested. players. Without going any further, a few hours ago, Razer added the Stream Controller X to its ecosystem, a new controller designed to make life easier for these content creators thanks to the features that we are going to review in the next few lines. This is the Razer Stream Controller We therefore find a controller that has 15 fully programmable LCD buttons with a compact form factor with which creators can quickly access lighting effects, sounds, switch between scenes or applications or control sound. This device uses the Loupedeck software, being compatible with the main streaming or video creation platforms such as OBS Studio, Streamlabs, Adobe Premier Pro, Twitch and other tools. With access to Louperdeck, creators can install apps, plugins, and even emotes to enhance their videos or live content. These po[CENSORED]r plugins include Spotify, Phillips Hue, Adobe Photoshop, and even Voicemod, which can help streamline creative processes. In addition, Loupedeck's full suite software also gives users access to native profiles that are preset, for added convenience and inspiration. As for the price, this interface with the aforementioned 15 buttons, multi-link macros and 50° detachable anti-slip magnetic support goes on sale today at a price of €179.99. https://vandal.elespanol.com/noticia/w5991/razer-anuncia-el-stream-controller-x-una-nueva-herramienta-para-creadores-de-contenido

Nickname: @Phoenix™ Video author: DarkPlayer GamingTV Name of the game: RESIDENT EVIL 2 REMAKE Link video: Rate this video 1-10:10/10